WICH phosphorylates H2AFX on Y142

Stable Identifier
R-HSA-5683930
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Under basal conditions, histone H2AFX (H2AX) is phosphorylated on tyrosine residue Y142 by the WICH complex composed of BAZ1B (WSTF) and SMARCA5 (SNF2H) (Xiao et al. 2009).

Literature References
PubMed ID Title Journal Year
19092802 WSTF regulates the H2A.X DNA damage response via a novel tyrosine kinase activity

Xiao, A, Li, H, Shechter, D, Ahn, SH, Fabrizio, LA, Erdjument-Bromage, H, Ishibe-Murakami, S, Wang, B, Tempst, P, Hofmann, K, Patel, DJ, Elledge, SJ, Allis, CD

Nature 2009
Participants
Participates
Catalyst Activity

protein tyrosine kinase activity of WICH [nucleoplasm]

Orthologous Events
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