PLK1 hyperphosphorylates Condensin II complex

Stable Identifier
R-HSA-2294580
Type
Reaction
Species
Homo sapiens
Compartment
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Once PLK1 is recruited to the chromatin-bound condensin II complex, it phosphorylates the NCAPD3 subunit of condensin II on serine residue S1419, and possibly other residues. In addition to phosphorylating NCAPD3, PLK1 phosphorylates other condensin II subunits, NCAPG2 and NCAPH2. However, the phosphorylation sites have not yet been determined. PLK1-mediated phosphorylation of the condensin II complex facilitates condensation of prophase chromosomes (Abe et al. 2011).

Literature References
PubMed ID Title Journal Year
21498573 The initial phase of chromosome condensation requires Cdk1-mediated phosphorylation of the CAP-D3 subunit of condensin II

Nagasaka, K, Hirota, T, Aoyagi, Y, Abe, S, Kozuka-Hata, H, Obuse, C, Oyama, M, Hirayama, Y

Genes Dev. 2011
Participants
Participates
Catalyst Activity

protein serine/threonine kinase activity of p-T210-PLK1:Phosphorylated Condensin II:Nucleosome [nucleoplasm]

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