ATM phosphorylates TTC5

Stable Identifier
R-HSA-6804276
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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ATM phosphorylates TTC5 (Strap), a cofactor of TP53 (p53), on serine residue S203. Phosphorylation of S203 induces nuclear accumulation of TTC5, probably by interfering with the nuclear export signal at the N-terminus of TTC5 (Demonacos et al. 2004, Adams et al. 2008).
Literature References
PubMed ID Title Journal Year
15448695 A new effector pathway links ATM kinase with the DNA damage response

Smith, L, Xu, D, Jansson, M, La Thangue, NB, Krstic-Demonacos, M, O'Connor, DP, Demonacos, C

Nat. Cell Biol. 2004
18833288 ATM and Chk2 kinase target the p53 cofactor Strap

Coutts, AS, Smith, L, Adams, CJ, Edelmann, M, Jansson, M, La Thangue, NB, Kessler, B, Graham, AL

EMBO Rep. 2008
Participants
Participates
Catalyst Activity

protein serine/threonine kinase activity of p-S1981,Ac-K3016-ATM [nucleoplasm]

Orthologous Events
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