Phosphorylation of NBS1 by ATM

Stable Identifier
R-GGA-351455
Type
Reaction [transition]
Species
Gallus gallus
Compartment
nucleoplasm
ReviewStatus
5/5
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Phosphorylation of NBS1 by ATM
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Upon formation of DSBs, MRN (MRE11-RAD50-NBS1) complex is transported to the nucleus independent of ATM. Localization of the MRN complex to the DNA damage site is required for proper activation of ATM. At the damage site, activated ATM phosphorylates H2AX (yielding gamma-H2AX) and NBS1. Although NBS1 and gamma-H2AX interact, the sequence of events is unclear. NBS1 may initially form a complex with gamma-H2AX, and then become phosphorylated by ATM. Alternatively, phospho-NBS1 may be recruited to the DSB by complex formation with gamma-H2AX.
Literature References
PubMed ID Title Journal Year
16824197 ATM activation by a sulfhydryl-reactive inflammatory cyclopentenone prostaglandin

Shimizu, H, Mihara, K, Tauchi, H, Uchida, K, Shibata, T, Ono, H, Yamamoto, K, Komatsu, K, Kobayashi, M

Genes Cells 2006
12422221 Nbs1 is essential for DNA repair by homologous recombination in higher vertebrate cells

Matsuura, S, Nakamura, A, Morishima, K, Takeda, S, Tauchi, H, Ito, E, vanHeems, D, Sonoda, E, Verkaik, NS, Takata, M, Kobayashi, J, Shiraishi, T, van Gent, DC, Komatsu, K

Nature 2002
Participants
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Output
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as an event of
Catalyst Activity

protein serine/threonine kinase activity of ATM [nucleoplasm]

Physical Entity
ATM [nucleoplasm] (Gallus gallus)
Activity
protein serine/threonine kinase activity (GO:0004674)
Authored
Saxena, A  (2008-07-07)
Reviewed
Borowiec, JA  (2009-04-24)
Created
Saxena, A  (2008-05-23)
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