Reactome | CDK1 phosphorylates LPIN

CDK1 phosphorylates LPIN

Stable Identifier

R-HSA-5195402

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

Locations in the PathwayBrowser

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Cell Cycle (Homo sapiens)

- Cell Cycle, Mitotic (Homo sapiens)
  - M Phase (Homo sapiens)
    - Mitotic Prophase (Homo sapiens)
      - Nuclear Envelope Breakdown (Homo sapiens)
        
        Depolymerization of the Nuclear Lamina (Homo sapiens)
        
        CDK1 phosphorylates LPIN (Homo sapiens)

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Lipins (LPIN1, LPIN2, LPIN3) possess several proline-directed phosphorylation sites that can be phosphorylated by CDK1 (Grimsey et al. 2008), including S106. Serine S106 in lipins is a preferred target for dephosphorylation by the evolutionarilly conserved CTDNEP1:CNEP1R1 complex (ortholog of yeast NEM1:SPO7 complex). Lipin phosphorylation regulates lipin localization, with phosphorylated lipins being soluble and dephosphorylated lipins being membrane-bound. The yeast ortholog of CDK1, CDC28, as well as human CDK1 can phosphorylate yeast lipin PAH1, inducing its dissociation from the nuclear envelope and endoplasmic reticulum membrane (Choi et al. 2011).

Literature References

PubMed ID	Title	Journal	Year
20876142	A phosphorylation-regulated amphipathic helix controls the membrane translocation and function of the yeast phosphatidate phosphatase Karanasios, E, Han, GS, Xu, Z, Carman, GM, Siniossoglou, S	Proc. Natl. Acad. Sci. U.S.A.	2010
18694939	Temporal and spatial regulation of the phosphatidate phosphatases lipin 1 and 2 Grimsey, N, Han, GS, O'Hara, L, Rochford, JJ, Carman, GM, Siniossoglou, S	J Biol Chem	2008
21081492	Phosphorylation of phosphatidate phosphatase regulates its membrane association and physiological functions in Saccharomyces cerevisiae: identification of SER(602), THR(723), AND SER(744) as the sites phosphorylated by CDC28 (CDK1)-encoded cyclin-dependent kinase Choi, HS, Su, WM, Morgan, JM, Han, GS, Xu, Z, Karanasios, E, Siniossoglou, S, Carman, GM	J. Biol. Chem.	2011