Reactome | AKT3 phosphorylates TBX3

AKT3 phosphorylates TBX3

Stable Identifier

R-HSA-9825704

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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The transcription factor TBX3 is overexpressed in many cancers, and contributes to melanoma by directly repressing CDH1 gene expression, thus contributing to changes in motility and invasiveness (Rodriguez et al, 2008; Bosserhoff et al, 2011). AKT3-dependent phosphorylation of TBX3 increases its ability to repress transcription at the CDH1 promoter (Peres and Prince, 2013; Peres et al, 2010; Peres et al, 2015; Peres et al, 2021).

Literature References

PubMed ID	Title	Journal	Year
11323412	Loss of E-cadherin expression in melanoma cells involves up-regulation of the transcriptional repressor Snail Buettner, R, Domínguez, D, Bosserhoff, AK, de Herreros, AG, Poser, I, Varnai, A	J Biol Chem	2001
21779450	The Highly Homologous T-Box Transcription Factors, TBX2 and TBX3, Have Distinct Roles in the Oncogenic Process Bennett, DC, Peres, J, Prince, S, Davis, E, Wansleben, S, Mowla, S, Li, JA	Genes Cancer	2010
25595898	The T-box transcription factor, TBX3, is a key substrate of AKT3 in melanomagenesis Peres, J, Prince, S, Mowla, S	Oncotarget	2015
18829543	Tbx3 represses E-cadherin expression and enhances melanoma invasiveness Aladowicz, E, Lanfrancone, L, Rodriguez, M, Goding, CR	Cancer Res	2008
24098938	The T-box transcription factor, TBX3, is sufficient to promote melanoma formation and invasion Peres, J, Prince, S	Mol Cancer	2013
21496114	Melanoblasts in culture as an in vitro system to determine molecular changes in melanoma Kuphal, S, Ellmann, L, Bosserhoff, AK	Exp Dermatol	2011
33744299	TBX3 Promotes Melanoma Migration by Transcriptional Activation of ID1, which Prevents Activation of E-Cadherin by MITF Peres, J, Galibert, MD, Prince, S, Popovic, A, Goding, CR, Damerell, V, Chauhan, J, Desprez, PY	J Invest Dermatol	2021