GSK3B phosphorylates RUNX2

Stable Identifier
R-HSA-9008480
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
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GSK3B phosphorylates RUNX2
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GSK3B phosphorylates RUNX2 on three serine residues in an evolutionarily conserved motif SPPWSYDQS, which decreases the DNA binding ability of RUNX2 (Kugimiya et al. 2007, Kumar et al. 2015).

Literature References
PubMed ID Title Journal Year
26542806 E3 Ubiquitin Ligase Fbw7 Negatively Regulates Osteoblast Differentiation by Targeting Runx2 for Degradation

Kumar, Y, Kapoor, I, Khan, K, Thacker, G, Khan, MP, Shukla, N, Kanaujiya, JK, Sanyal, S, Chattopadhyay, N, Trivedi, AK

J. Biol. Chem. 2015
17786208 GSK-3beta controls osteogenesis through regulating Runx2 activity

Kugimiya, F, Kawaguchi, H, Ohba, S, Kawamura, N, Hirata, M, Chikuda, H, Azuma, Y, Woodgett, JR, Nakamura, K, Chung, UI

PLoS ONE 2007
Participants
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Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine kinase activity of RUNX2:GSK3B [nucleoplasm]
Physical Entity
RUNX2:GSK3B [nucleoplasm]
Activity
protein serine/threonine kinase activity (0004674)
Inferred From
GSK3B phosphorylates Runx2 (Homo sapiens)
Authored
Orlic-Milacic, M  (2017-06-10)
Reviewed
Ducy, P  (2017-08-04)
Created
Orlic-Milacic, M  (2017-06-10)