GSK3B phosphorylates RUNX2 on three serine residues in an evolutionarily conserved motif SPPWSYDQS, which decreases the DNA binding ability of RUNX2 (Kugimiya et al. 2007, Kumar et al. 2015).
Kumar, Y, Kapoor, I, Khan, K, Thacker, G, Khan, MP, Shukla, N, Kanaujiya, JK, Sanyal, S, Chattopadhyay, N, Trivedi, AK
Kugimiya, F, Kawaguchi, H, Ohba, S, Kawamura, N, Hirata, M, Chikuda, H, Azuma, Y, Woodgett, JR, Nakamura, K, Chung, UI
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