GSK3B phosphorylates RUNX2

Stable Identifier
R-HSA-9008480
Type
Reaction
Species
Homo sapiens
Compartment
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GSK3B phosphorylates RUNX2 on three serine residues in an evolutionarily conserved motif SPPWSYDQS, which decreases the DNA binding ability of RUNX2 (Kugimiya et al. 2007, Kumar et al. 2015).

Literature References
PubMed ID Title Journal Year
17786208 GSK-3beta controls osteogenesis through regulating Runx2 activity

Woodgett, JR, Kawamura, N, Ohba, S, Kawaguchi, H, Kugimiya, F, Chung, UI, Nakamura, K, Chikuda, H, Azuma, Y, Hirata, M

PLoS ONE 2007
26542806 E3 Ubiquitin Ligase Fbw7 Negatively Regulates Osteoblast Differentiation by Targeting Runx2 for Degradation

Khan, MP, Kumar, Y, Trivedi, AK, Kanaujiya, JK, Kapoor, I, Sanyal, S, Thacker, G, Khan, K, Chattopadhyay, N, Shukla, N

J. Biol. Chem. 2015
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Catalyst Activity

protein serine/threonine kinase activity of RUNX2:GSK3B [nucleoplasm]

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