p-T182 MAPKAPK5 phosphorylates FOXO1

Stable Identifier
R-HSA-5692779
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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p-T182 MAPKAPK5 phosphorylates FOXO1
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MAPKAPK5 phosphorylates FOXO1 at S218 (corresponds to S215 in mouse Foxo1). This phosphorylation is essential for the FOXO1-dependent activation of RAG gene transcription during B-cell development and promotes the direct binding of FOXO1 to the RAG gene promoter (Chow et al, 2013).
Literature References
PubMed ID Title Journal Year
23878308 MK5 activates Rag transcription via Foxo1 in developing B cells

Chow, KT, Timblin, GA, McWhirter, SM, Schlissel, MS

J. Exp. Med. 2013
Participants
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Output
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as an event of
Catalyst Activity

protein serine/threonine kinase activity of p-T182-MAPKAPK5 [nucleoplasm]

Physical Entity
p-T182-MAPKAPK5 [nucleoplasm] (Homo sapiens)
Activity
protein serine/threonine kinase activity (GO:0004674)
Orthologous Events
p-T182 MAPKAPK5 phosphorylates FOXO1 (Bos taurus)
p-T182 MAPKAPK5 phosphorylates FOXO1 (Danio rerio)
p-T182 MAPKAPK5 phosphorylates FOXO1 (Gallus gallus)
p-T182 MAPKAPK5 phosphorylates FOXO1 (Mus musculus)
p-T182 MAPKAPK5 phosphorylates FOXO1 (Rattus norvegicus)
p-T182 MAPKAPK5 phosphorylates FOXO1 (Sus scrofa)
Authored
Meloche, S  (2015-05-12)
Reviewed
Soulez, M  (2015-05-12)
Mathien, S  (2015-05-12)
Meloche, S  (2015-05-12)
Created
Rothfels, K  (2015-05-13)
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