Reactome | ATM phosphorylates TP53BP1 at DNA DSBs

ATM phosphorylates TP53BP1 at DNA DSBs

Stable Identifier

R-HSA-5683425

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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Activated ATM hyper-phosphorylates TP53BP1 (53BP1) at multiple residues in response to DNA damage (Fernandez-Capetillo et al. 2002, Ward et al. 2003, Jowsey et al. 2007). Phosphorylation of TP53BP1 serine residues S25 and S1778 is important for the retention of TP53BP1 at DNA double-strand break (DSB) sites (Kang et al. 2009).

Literature References

PubMed ID	Title	Journal	Year
12447390	DNA damage-induced G2-M checkpoint activation by histone H2AX and 53BP1 Fernandez-Capetillo, O, Chen, HT, Celeste, A, Ward, I, Romanienko, PJ, Morales, JC, Naka, K, Xia, Z, Camerini-Otero, RD, Motoyama, N, Carpenter, PB, Bonner, WM, Chen, J, Nussenzweig, A	Nat. Cell Biol.	2002
12697768	Accumulation of checkpoint protein 53BP1 at DNA breaks involves its binding to phosphorylated histone H2AX Ward, IM, Minn, K, Jorda, KG, Chen, J	J. Biol. Chem.	2003
19176521	Protein phosphatase 5 regulates the function of 53BP1 after neocarzinostatin-induced DNA damage Kang, Y, Lee, JH, Hoan, NN, Sohn, HM, Chang, IY, You, HJ	J. Biol. Chem.	2009
17553757	Characterisation of the sites of DNA damage-induced 53BP1 phosphorylation catalysed by ATM and ATR Jowsey, P, Morrice, NA, Hastie, CJ, McLauchlan, H, Toth, R, Rouse, J	DNA Repair (Amst.)	2007

Participants

Input

Output

Participates

as an event of

Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks (Homo sapiens)

Catalyst Activity

protein serine/threonine kinase activity of DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:TP53BP1 [nucleoplasm]

Physical Entity

DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:TP53BP1 [nucleoplasm] (Homo sapiens)

Activity

protein serine/threonine kinase activity (GO:0004674)

Orthologous Events

ATM phosphorylates TP53BP1 at DNA DSBs (Bos taurus)

ATM phosphorylates TP53BP1 at DNA DSBs (Canis familiaris)

ATM phosphorylates TP53BP1 at DNA DSBs (Danio rerio)

ATM phosphorylates TP53BP1 at DNA DSBs (Gallus gallus)

ATM phosphorylates TP53BP1 at DNA DSBs (Mus musculus)

ATM phosphorylates TP53BP1 at DNA DSBs (Rattus norvegicus)

ATM phosphorylates TP53BP1 at DNA DSBs (Sus scrofa)