ATM phosphorylates TP53BP1 at DNA DSBs

Stable Identifier
R-HSA-5683425
Type
Reaction [transition]
Species
Homo sapiens
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Activated ATM hyper-phosphorylates TP53BP1 (53BP1) at multiple residues in response to DNA damage (Fernandez-Capetillo et al. 2002, Ward et al. 2003, Jowsey et al. 2007). Phosphorylation of TP53BP1 serine residues S25 and S1778 is important for the retention of TP53BP1 at DNA double strand break (DSB) sites (Kang et al. 2009).

Literature References
PubMed ID Title Journal Year
12697768 Accumulation of checkpoint protein 53BP1 at DNA breaks involves its binding to phosphorylated histone H2AX

Ward, IM, Minn, K, Jorda, KG, Chen, J

J. Biol. Chem. 2003
12447390 DNA damage-induced G2-M checkpoint activation by histone H2AX and 53BP1

Fernandez-Capetillo, O, Chen, HT, Celeste, A, Ward, I, Romanienko, PJ, Morales, JC, Naka, K, Xia, Z, Camerini-Otero, RD, Motoyama, N, Carpenter, PB, Bonner, WM, Chen, J, Nussenzweig, A

Nat. Cell Biol. 2002
19176521 Protein phosphatase 5 regulates the function of 53BP1 after neocarzinostatin-induced DNA damage

Kang, Y, Lee, JH, Hoan, NN, Sohn, HM, Chang, IY, You, HJ

J. Biol. Chem. 2009
17553757 Characterisation of the sites of DNA damage-induced 53BP1 phosphorylation catalysed by ATM and ATR

Jowsey, P, Morrice, NA, Hastie, CJ, McLauchlan, H, Toth, R, Rouse, J

DNA Repair (Amst.) 2007
Participants
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Catalyst Activity
Catalyst Activity
Title
protein serine/threonine kinase activity of DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:TP53BP1 [nucleoplasm]
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