1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/2 in the nucleus

Stable Identifier
R-HSA-1855157
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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In the nucleus, inositol hexakisphosphate kinase 1 (IP6K1) and 2 (IP6K2) phosphorylate 1-diphospho-2,3,4,5,6-pentakisphosphate (1-PP-IP5) to make inositol 1,5-bisdiphospho-2,3,4,6-tetrakisphosphate (1,5-(PP)2-IP4) (Saiardi et al. 2001, Mulugu et al. 2007).

Literature References
PubMed ID Title Journal Year
17412958 A conserved family of enzymes that phosphorylate inositol hexakisphosphate

Mulugu, S, Bai, W, Fridy, PC, Bastidas, RJ, Otto, JC, Dollins, DE, Haystead, TA, Ribeiro, AA, York, JD

Science 2007
11502751 Identification and characterization of a novel inositol hexakisphosphate kinase

Saiardi, A, Nagata, E, Luo, HR, Snowman, AM, Snyder, SH

J Biol Chem 2001
Participants
Participates
Catalyst Activity

inositol heptakisphosphate kinase activity of IP6K1/2 [nucleoplasm]

Orthologous Events
Cross References
Rhea
Authored
Reviewed
Created
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