CHEK1 phosphorylates BRCA2

Stable Identifier
R-HSA-5685242
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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CHEK1 phosphorylates BRCA2 on threonine residue T3887, in the C-terminal region of BRCA2. CHEK1-mediated BRCA2 phosphorylation, as well as CHEK1 mediated RAD51 phosphorylation, promotes the association of BRCA2 with RAD51 (Bahassi et al. 2008).

Literature References
PubMed ID Title Journal Year
18317453 The checkpoint kinases Chk1 and Chk2 regulate the functional associations between hBRCA2 and Rad51 in response to DNA damage

Bahassi, EM, Ovesen, JL, Riesenberg, AL, Bernstein, WZ, Hasty, PE, Stambrook, PJ

Oncogene 2008
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine kinase activity of p-S317,S345-CHEK1 [nucleoplasm]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created