ERK5 activates the transcription factor MEF2

Stable Identifier
R-HSA-199929
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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The MEF2 (Myocyte-specific enhancer factor 2) proteins constitute a family of transcription factors: MEF2A, MEF2B, MEF2C, and MEF2D. MEF2A and MEF2C are known substrates of ERK5, and their transactivating activity can be stimulated by ERK5 via direct phosphorylation. MEF2A and MEF2C are expressed in developing and adult brain including cortex and cerebellum.

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Catalyst Activity

protein serine/threonine kinase activity of p-T218,Y220-MAPK7 [nucleoplasm]

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