NUAK1 phosphorylates TP53

Stable Identifier
R-HSA-3222020
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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NUAK1, activated by STK11 (LKB1)-mediated phosphorylation on threonine residue T211, phosphorylates TP53 (p53) on serine residues S15 and S392, contributing to TP53-mediated transcriptional activation of the CDKN1A (p21) gene (Zeng and Berger 2006, Hou et al. 2011).
Literature References
PubMed ID Title Journal Year
21317932 A new role of NUAK1: directly phosphorylating p53 and regulating cell proliferation

Liu, JE, Liu, ZY, Liu, W, Sun, ZY, Liu, CY, Hou, X

Oncogene 2011
Participants
Participates
Catalyst Activity

protein serine/threonine kinase activity of TP53 Tetramer:STK11:p-T211-NUAK1 [nucleoplasm]

Orthologous Events
Authored
Reviewed
Created
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