PKN1 phosphorylates histone 3 of nucleosomes associate with KLK2 and KLK3 promoters

Stable Identifier
R-HSA-5625784
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
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PKN1 phosphorylates histone 3 of nucleosomes associate with KLK2 and KLK3 promoters
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PKN1 (PRK1), recruited to promoters of KLK2 and KLK3 (PSA) genes through association with the activated androgen receptor (AR), phosphorylates promoter-bound nucleosomes on threonine residue T12 (also labeled as T11 in literature) of histone 3, creating the H3T11 mark (Metzger et al. 2008).

Literature References
PubMed ID Title Journal Year
18066052 Phosphorylation of histone H3 at threonine 11 establishes a novel chromatin mark for transcriptional regulation

Metzger, E, Yin, N, Wissmann, M, Kunowska, N, Fischer, K, Friedrichs, N, Patnaik, D, Higgins, JM, Potier, N, Scheidtmann, KH, Buettner, R, Schüle, R

Nat. Cell Biol. 2008
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Catalyst Activity
Title
protein kinase C activity of p-T774-PKN1:AR:Androgen:KLK2,3 Gene:Nucleosome with Me3K-10-H3 [nucleoplasm]
Physical Entity
p-T774-PKN1:AR:Androgen:KLK2,3 Gene:Nucleosome with Me3K-10-H3 [nucleoplasm]
Activity
protein kinase C activity (0004697)
Orthologous Events
PKN1 phosphorylates histone 3 of nucleosomes associate with KLK2 and KLK3 promoters (Bos taurus)
PKN1 phosphorylates histone 3 of nucleosomes associate with KLK2 and KLK3 promoters (Caenorhabditis elegans)
PKN1 phosphorylates histone 3 of nucleosomes associate with KLK2 and KLK3 promoters (Canis familiaris)
PKN1 phosphorylates histone 3 of nucleosomes associate with KLK2 and KLK3 promoters (Danio rerio)
PKN1 phosphorylates histone 3 of nucleosomes associate with KLK2 and KLK3 promoters (Drosophila melanogaster)
PKN1 phosphorylates histone 3 of nucleosomes associate with KLK2 and KLK3 promoters (Gallus gallus)
PKN1 phosphorylates histone 3 of nucleosomes associate with KLK2 and KLK3 promoters (Mus musculus)
PKN1 phosphorylates histone 3 of nucleosomes associate with KLK2 and KLK3 promoters (Rattus norvegicus)
PKN1 phosphorylates histone 3 of nucleosomes associate with KLK2 and KLK3 promoters (Sus scrofa)
PKN1 phosphorylates histone 3 of nucleosomes associate with KLK2 and KLK3 promoters (Xenopus tropicalis)
Authored
Orlic-Milacic, M  (2014-10-24)
Rivero Crespo, F  (2014-12-26)
Created
Orlic-Milacic, M  (2014-10-07)