Reactome | PKN1 phosphorylates histone 3 of nucleosomes associate with KLK2 and KLK3 promoters

PKN1 phosphorylates histone 3 of nucleosomes associate with KLK2 and KLK3 promoters

Stable Identifier

R-HSA-5625784

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

Locations in the PathwayBrowser

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Signal Transduction (Homo sapiens)

- Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
  - Signaling by Rho GTPases (Homo sapiens)
    - RHO GTPase Effectors (Homo sapiens)
      - RHO GTPases activate PKNs (Homo sapiens)
        
        Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 (Homo sapiens)
        
        PKN1 phosphorylates histone 3 of nucleosomes associate with KLK2 and KLK3 promoters (Homo sapiens)

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PKN1 phosphorylates histone 3 of nucleosomes associate with KLK2 and KLK3 promoters

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PKN1 (PRK1), recruited to promoters of KLK2 and KLK3 (PSA) genes through association with the activated androgen receptor (AR), phosphorylates promoter-bound nucleosomes on threonine residue T12 (also labeled as T11 in literature) of histone 3, creating the H3T11 mark (Metzger et al. 2008).

Literature References

PubMed ID	Title	Journal	Year
18066052	Phosphorylation of histone H3 at threonine 11 establishes a novel chromatin mark for transcriptional regulation Metzger, E, Yin, N, Wissmann, M, Kunowska, N, Fischer, K, Friedrichs, N, Patnaik, D, Higgins, JM, Potier, N, Scheidtmann, KH, Buettner, R, Schüle, R	Nat. Cell Biol.	2008