I(1,4,5,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus

Stable Identifier
R-HSA-1855185
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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I(1,4,5,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus
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In the nucleus, inositol polyphosphate multikinase (IPMK) phosphorylates inositol 1,4,5,6-tetrakisphosphate (I(1,4,5,6)P4) to inositol 1,3,4,5,6-pentakisphosphate (I(1,3,4,5,6)P5) (Nalaskowski et al. 2002, Chang & Majerus 2006).
Literature References
PubMed ID Title Journal Year
16293229 Inositol polyphosphate multikinase regulates inositol 1,4,5,6-tetrakisphosphate

Chang, SC, Majerus, PW

Biochem Biophys Res Commun 2006
12027805 The human homologue of yeast ArgRIII protein is an inositol phosphate multikinase with predominantly nuclear localization

Nalaskowski, MM, Deschermeier, C, Fanick, W, Mayr, GW

Biochem J 2002
Participants
Input
Output
Participates
as an event of
Catalyst Activity

inositol-1,4,5,6-tetrakisphosphate 3-kinase activity of IPMK [nucleoplasm]

Physical Entity
IPMK [nucleoplasm] (Homo sapiens)
Activity
inositol-1,4,5,6-tetrakisphosphate 3-kinase activity (GO:0000824)
Orthologous Events
I(1,4,5,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus (Bos taurus)
I(1,4,5,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus (Caenorhabditis elegans)
I(1,4,5,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus (Canis familiaris)
I(1,4,5,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus (Danio rerio)
I(1,4,5,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus (Dictyostelium discoideum)
I(1,4,5,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus (Drosophila melanogaster)
I(1,4,5,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus (Mus musculus)
I(1,4,5,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus (Plasmodium falciparum)
I(1,4,5,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus (Rattus norvegicus)
I(1,4,5,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus (Xenopus tropicalis)
Cross References
RHEA
Authored
Williams, MG  (2011-10-28)
Reviewed
Wundenberg, T  (2012-11-07)
D'Eustachio, P  (2025-09-23)
Created
Williams, MG  (2011-10-28)
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