HIPK2 phosphorylates MECP2

Stable Identifier
R-HSA-9022314
Type
Reaction [transition]
Species
Homo sapiens
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Nuclear serine/threonine protein kinase HIPK2 phosphorylates MECP2 on serine residue S80 (Bracaglia et al. 2009). Phosphorylation of MECP2 at S80 correlates with low neuronal activity. Upon neuronal activation, calcium influx stimulates dephosphorylation at S80 (Tao et al. 2009).

Literature References
PubMed ID Title Journal Year
19820693 Methyl-CpG-binding protein 2 is phosphorylated by homeodomain-interacting protein kinase 2 and contributes to apoptosis

Bracaglia, G, Conca, B, Bergo, A, Rusconi, L, Zhou, Z, Greenberg, ME, Landsberger, N, Soddu, S, Kilstrup-Nielsen, C

EMBO Rep. 2009
19225110 Phosphorylation of MeCP2 at Serine 80 regulates its chromatin association and neurological function

Tao, J, Hu, K, Chang, Q, Wu, H, Sherman, NE, Martinowich, K, Klose, RJ, Schanen, C, Jaenisch, R, Wang, W, Sun, YE

Proc. Natl. Acad. Sci. U.S.A. 2009
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Catalyst Activity
Title
protein serine/threonine kinase activity of HIPK2 [nucleoplasm]
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Orthologous Events
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