Reactome | HIPK2 phosphorylates MECP2

HIPK2 phosphorylates MECP2

Stable Identifier

R-HSA-9022314

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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Nuclear serine/threonine protein kinase HIPK2 phosphorylates MECP2 on serine residue S80 (Bracaglia et al. 2009). Phosphorylation of MECP2 at S80 correlates with low neuronal activity. Upon neuronal activation, calcium influx stimulates dephosphorylation at S80 (Tao et al. 2009).

Literature References

PubMed ID	Title	Journal	Year
19225110	Phosphorylation of MeCP2 at Serine 80 regulates its chromatin association and neurological function Sun, YE, Klose, RJ, Wu, H, Jaenisch, R, Tao, J, Sherman, NE, Martinowich, K, Schanen, C, Wang, W, Chang, Q, Hu, K	Proc. Natl. Acad. Sci. U.S.A.	2009
19820693	Methyl-CpG-binding protein 2 is phosphorylated by homeodomain-interacting protein kinase 2 and contributes to apoptosis Greenberg, ME, Conca, B, Kilstrup-Nielsen, C, Landsberger, N, Bergo, A, Soddu, S, Rusconi, L, Bracaglia, G, Zhou, Z	EMBO Rep.	2009