Reactome | Phosphorylation of E2F1/E2F3 by Cyclin A:phosph-Cdk2(Thr 160)

Phosphorylation of E2F1/E2F3 by Cyclin A:phosph-Cdk2(Thr 160)

Stable Identifier

R-HSA-187959

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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Phosphorylation of E2F1/E2F3 by Cyclin A:phosph-Cdk2(Thr 160)

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In G2 Cdk2, in association with cyclin A, phosphorylates E2F1 and E2F3 resulting in the inactivation and possibly degradation of these two transcription factors (Dynlacht et al., 1994; Krek et al., 1994).

Literature References

PubMed ID	Title	Journal	Year
8033208	Negative regulation of the growth-promoting transcription factor E2F-1 by a stably bound cyclin A-dependent protein kinase Livingston, DM, Arany, Z, Kaelin WG, Jr, Krek, W, Ewen, ME, Shirodkar, S	Cell	1994
7958856	Differential regulation of E2F transactivation by cyclin/cdk2 complexes Flores, O, Lees, JA, Dynlacht, BD, Harlow, E	Genes Dev	1994