Phosphorylation of E2F1/E2F3 by Cyclin A:phosph-Cdk2(Thr 160)

Stable Identifier
R-HSA-187959
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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In G2 Cdk2, in association with cyclin A, phosphorylates E2F1 and E2F3 resulting in the inactivation and possibly degradation of these two transcription factors (Dynlacht et al., 1994; Krek et al., 1994).

Literature References
PubMed ID Title Journal Year
7958856 Differential regulation of E2F transactivation by cyclin/cdk2 complexes

Dynlacht, BD, Flores, O, Lees, JA, Harlow, E

Genes Dev 1994
8033208 Negative regulation of the growth-promoting transcription factor E2F-1 by a stably bound cyclin A-dependent protein kinase

Krek, W, Ewen, ME, Shirodkar, S, Arany, Z, Kaelin WG, Jr, Livingston, DM

Cell 1994
Participants
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
cyclin-dependent protein serine/threonine kinase activity of CCNA:p-T160-CDK2:E2F1/E2F3 [nucleoplasm]
Physical Entity
Activity
Orthologous Events
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Reviewed
Created