Phosphorylation of E2F1/E2F3 by Cyclin A:phosph-Cdk2(Thr 160)

Stable Identifier
R-HSA-187959
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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Phosphorylation of E2F1/E2F3 by Cyclin A:phosph-Cdk2(Thr 160)
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In G2 Cdk2, in association with cyclin A, phosphorylates E2F1 and E2F3 resulting in the inactivation and possibly degradation of these two transcription factors (Dynlacht et al., 1994; Krek et al., 1994).
Literature References
PubMed ID Title Journal Year
8033208 Negative regulation of the growth-promoting transcription factor E2F-1 by a stably bound cyclin A-dependent protein kinase

Krek, W, Ewen, ME, Shirodkar, S, Arany, Z, Kaelin WG, Jr, Livingston, DM

Cell 1994
7958856 Differential regulation of E2F transactivation by cyclin/cdk2 complexes

Dynlacht, BD, Flores, O, Lees, JA, Harlow, E

Genes Dev 1994
Participants
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Output
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as an event of
Catalyst Activity

cyclin-dependent protein serine/threonine kinase activity of CCNA:p-T160-CDK2:E2F1/E2F3 [nucleoplasm]

Physical Entity
CCNA:p-T160-CDK2:E2F1/E2F3 [nucleoplasm] (Homo sapiens)
Activity
cyclin-dependent protein serine/threonine kinase activity (GO:0004693)
Orthologous Events
Phosphorylation of E2F1/E2F3 by Cyclin A:phosph-Cdk2(Thr 160) (Bos taurus)
Phosphorylation of E2F1/E2F3 by Cyclin A:phosph-Cdk2(Thr 160) (Caenorhabditis elegans)
Phosphorylation of E2F1/E2F3 by Cyclin A:phosph-Cdk2(Thr 160) (Canis familiaris)
Phosphorylation of E2F1/E2F3 by Cyclin A:phosph-Cdk2(Thr 160) (Danio rerio)
Phosphorylation of E2F1/E2F3 by Cyclin A:phosph-Cdk2(Thr 160) (Dictyostelium discoideum)
Phosphorylation of E2F1/E2F3 by Cyclin A:phosph-Cdk2(Thr 160) (Drosophila melanogaster)
Phosphorylation of E2F1/E2F3 by Cyclin A:phosph-Cdk2(Thr 160) (Gallus gallus)
Phosphorylation of E2F1/E2F3 by Cyclin A:phosph-Cdk2(Thr 160) (Mus musculus)
Phosphorylation of E2F1/E2F3 by Cyclin A:phosph-Cdk2(Thr 160) (Rattus norvegicus)
Phosphorylation of E2F1/E2F3 by Cyclin A:phosph-Cdk2(Thr 160) (Sus scrofa)
Phosphorylation of E2F1/E2F3 by Cyclin A:phosph-Cdk2(Thr 160) (Xenopus tropicalis)
Authored
Pagano, M  (2006-09-19)
Reviewed
Coqueret, O  (2006-10-06)
Created
Matthews, L  (2006-09-29)
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