CAK-mediated phosphorylation of Cyclin A:Cdk2

Stable Identifier
R-HSA-187949
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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CAK-mediated phosphorylation of Cyclin A:Cdk2
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Phosphorylation of cyclin-dependent kinases (CDKs) by the CDK-activating kinase (CAK) is required for the activation of the CDK kinase activity. The association of p21/p27 with the Cyclin A/E:Cdk2 complex prevents CAK mediated phosphorylation of Cdk2 (Aprelikova et al., 1995).

Literature References
Participants
Input
Output
Participates
as an event of
Catalyst Activity

protein serine/threonine kinase activity of CAK [nucleoplasm]

Physical Entity
CAK [nucleoplasm] (Homo sapiens)
Activity
protein serine/threonine kinase activity (GO:0004674)
Orthologous Events
CAK-mediated phosphorylation of Cyclin A:Cdk2 (Bos taurus)
CAK-mediated phosphorylation of Cyclin A:Cdk2 (Canis familiaris)
CAK-mediated phosphorylation of Cyclin A:Cdk2 (Danio rerio)
CAK-mediated phosphorylation of Cyclin A:Cdk2 (Dictyostelium discoideum)
CAK-mediated phosphorylation of Cyclin A:Cdk2 (Drosophila melanogaster)
CAK-mediated phosphorylation of Cyclin A:Cdk2 (Gallus gallus)
CAK-mediated phosphorylation of Cyclin A:Cdk2 (Mus musculus)
CAK-mediated phosphorylation of Cyclin A:Cdk2 (Rattus norvegicus)
CAK-mediated phosphorylation of Cyclin A:Cdk2 (Schizosaccharomyces pombe)
CAK-mediated phosphorylation of Cyclin A:Cdk2 (Sus scrofa)
Authored
Pagano, M  (2006-09-19)
Reviewed
Coqueret, O  (2006-10-06)
Created
Matthews, L  (2006-09-29)
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