HIPK2 phosphorylates RUNX1 and EP300

Stable Identifier
Reaction [transition]
Homo sapiens
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HIPK2 can simultaneously phosphorylate RUNX1 and EP300 (p300) histone acetyltransferase bound to the RUNX1:CBFB complex. RUNX1 is phosphorylated by HIPK2 at serine residues S249 and S273 and threonine residue T276. EP300 is phosphorylated by HIPK2 at multiple serine and threonine residues that have not been thoroughly identified. HIPK2-mediated phosphorylation contributed to the activation of histone acetyltransferase activity of EP300 at RUNX1 target promoters (Aikawa et al. 2006, Wee et al. 2008).

Literature References
PubMed ID Title Journal Year
18695000 PEBP2-beta/CBF-beta-dependent phosphorylation of RUNX1 and p300 by HIPK2: implications for leukemogenesis

Ito, Y, Voon, DC, Wee, HJ, Bae, SC

Blood 2008
16917507 Roles of HIPK1 and HIPK2 in AML1- and p300-dependent transcription, hematopoiesis and blood vessel formation

Koseki, H, Schmitz, ML, Nguyen, LA, Takakura, N, Isono, K, Tagata, Y, Kitabayashi, I, Aikawa, Y

EMBO J. 2006
Catalyst Activity

protein serine/threonine kinase activity of HIPK2 [nucleoplasm]

Orthologous Events
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