Reactome | HIPK2 phosphorylates RUNX1 and EP300

HIPK2 phosphorylates RUNX1 and EP300

Stable Identifier

R-HSA-8878050

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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HIPK2 can simultaneously phosphorylate RUNX1 and EP300 (p300) histone acetyltransferase bound to the RUNX1:CBFB complex. RUNX1 is phosphorylated by HIPK2 at serine residues S249, S273, and S276. EP300 is phosphorylated by HIPK2 at multiple serine and threonine residues that have not been thoroughly identified. HIPK2-mediated phosphorylation contributed to the activation of histone acetyltransferase activity of EP300 at RUNX1 target promoters (Aikawa et al. 2006, Wee et al. 2008).

Literature References

PubMed ID	Title	Journal	Year
18695000	PEBP2-beta/CBF-beta-dependent phosphorylation of RUNX1 and p300 by HIPK2: implications for leukemogenesis Wee, HJ, Voon, DC, Bae, SC, Ito, Y	Blood	2008
16917507	Roles of HIPK1 and HIPK2 in AML1- and p300-dependent transcription, hematopoiesis and blood vessel formation Aikawa, Y, Nguyen, LA, Isono, K, Takakura, N, Tagata, Y, Schmitz, ML, Koseki, H, Kitabayashi, I	EMBO J.	2006