Activated ERKs phosphorylate ERF

Stable Identifier
R-HSA-3209160
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Activated ERKs phosphorylate ERF
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Activated ERKs (ERK1 i.e. MAPK3 and ERK2 i.e. MAPK1) phosphorylate ERF on threonine residue T526 and possibly other sites. The threonine T526 seems to be the dominant phosphorylation site and its functional relevance has been established (Sgouras et al. 1995, Le Gallic et al. 2004).
Literature References
PubMed ID Title Journal Year
14729966 ERF nuclear shuttling, a continuous monitor of Erk activity that links it to cell cycle progression

Cohen, P, Mavrothalassitis, G, Le Gallic, L, Biteau, B, Virgilio, L

Mol. Cell. Biol. 2004
7588608 ERF: an ETS domain protein with strong transcriptional repressor activity, can suppress ets-associated tumorigenesis and is regulated by phosphorylation during cell cycle and mitogenic stimulation

Mavrothalassitis, GJ, Fisher, RJ, Blair, DG, Athanasiou, MA, Beal, GJ, Sgouras, DN

EMBO J. 1995
Participants
Input
Output
Participates
as an event of
Catalyst Activity

protein serine/threonine kinase activity of p-T,Y MAPK dimers [nucleoplasm]

Physical Entity
p-T,Y MAPK dimers [nucleoplasm] (Homo sapiens)
Activity
protein serine/threonine kinase activity (GO:0004674)
Inferred From
Mapk1 (Erk2) phosphorylates ERF (Homo sapiens)
Authored
Orlic-Milacic, M  (2013-07-15)
Reviewed
Samarajiwa, S  (2013-09-03)
Created
Orlic-Milacic, M  (2013-03-01)
Cite Us!