Csnk1d,e phosphorylates Clock in p-S-Cry:p-S-Per:Csnk1d,e:p-S97,Ac-K544-Bmal1:p-T451,T461,S440,S441,S446-Clock:Nr1d1 gene

Stable Identifier
R-MMU-9927992
Type
Reaction [transition]
Species
Mus musculus
Compartment
nucleoplasm
ReviewStatus
5/5
General
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Csnk1d,e phosphorylates Clock in p-S-Cry:p-S-Per:Csnk1d,e:p-S97,Ac-K544-Bmal1:p-T451,T461,S440,S441,S446-Clock:Nr1d1 gene
Cry and Per proteins form complexes with the kinase Csnk1d (Ck1delta) and/or Csnk1e (Ck1epsilon) and bind the Bmal1:Clock heterodimer at promoters of target genes. The Cry:Per:kinase complex thereby brings Csnk1d and/or Csnk1e into proximity with Clock, resulting in the phosphorylation of Clock (Cao et al. 2021). The phosphorylation may occur at serine-38 and serine-42 in the DNA-binding domain of Clock (Yoshitane et al. 2009), as the phosphorylation of Clock by Csnk1d causes repression of Bmal1:Clock transactivation activity and dissociation of the Bmal1:Clock heterodimer from DNA (Cao et al. 2021).
Literature References
PubMed ID Title Journal Year
33443219 Molecular mechanism of the repressive phase of the mammalian circadian clock

Cao, X, Yang, Y, Selby, CP, Liu, Z, Sancar, A

Proc Natl Acad Sci U S A 2021
Participants
Input
Output
Catalyst Activity

protein serine/threonine kinase activity of p-S-Cry:p-S-Per:Csnk1d,e:p-S97,Ac-K544-Bmal1:p-T451,T461,S440,S441,S446-Clock:Nr1d1 gene [nucleoplasm]

Physical Entity
p-S-Cry:p-S-Per:Csnk1d,e:p-S97,Ac-K544-Bmal1:p-T451,T461,S440,S441,S446-Clock:Nr1d1 gene [nucleoplasm] (Mus musculus)
Activity
protein serine/threonine kinase activity (GO:0004674)
Orthologous Events
CSNK1D,E phosphorylates CLOCK in p-S-CRY:p-S-PER:CSNK1D,E:p-S90,Ac-538-BMAL:p-2T,3S-CLOCK:target gene (Homo sapiens)
Authored
May, B  (2024-11-10)
Reviewed
Sancar, A  (2025-02-14)
Albrecht, U  (2025-02-18)
Created
May, B  (2024-11-11)
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