Progesterone stimulation promotes PGR:P4 binding to ESR1:ESTG

Stable Identifier
Reaction [omitted]
Homo sapiens
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In addition to being a target of estrogen-dependent transcription, the progesterone receptor (PGR) interacts directly with ER alpha after stimulation with progesterone and modulates ESR1:ESTG binding (Ballare et al, 2003; Mohammed et al, 2015). Progesterone stimulation under estrogen-rich conditions promotes the release of PGR from the chaperone complex to facilitate interaction with ESR1 (Mohammed et al, 2015; reviewed in ).
Literature References
PubMed ID Title Journal Year
12612073 Two domains of the progesterone receptor interact with the estrogen receptor and are required for progesterone activation of the c-Src/Erk pathway in mammalian cells

Sancho, E, Uhrig, M, Auricchio, F, Di Domenico, M, Beato, M, Migliaccio, A, Bechtold, T, Ballaré, C

Mol. Cell. Biol. 2003
19274700 Breast cancer, estrogen receptor and ligands

Bai, Z, Gust, R

Arch. Pharm. (Weinheim) 2009
26153859 Progesterone receptor modulates ERα action in breast cancer

Tarulli, GA, Hadfield, J, Birrell, SN, Perou, CM, Hickey, TE, Serandour, AA, Launchbury, R, Pugh, M, Silva, G, Russell, IA, Bruna, A, Stingl, J, Caldas, C, Raj, GV, D'Santos, C, Saadi, A, Mohammed, H, Rueda, OM, Serandour, AA, Robinson, JL, Tilley, WD, Brown, GD, Stark, R, Menon, S, Carroll, JS

Nature 2015
Catalyst Activity

ATP hydrolysis activity of HSP90:ATP:PTGES3:FKBP52:PGR:P4 [nucleoplasm]

Orthologous Events
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