Reactome | Depolymerization of lamin filaments after PKC-mediated phosphorylation

Depolymerization of lamin filaments after PKC-mediated phosphorylation

Stable Identifier

R-HSA-5229194

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm, nuclear envelope

ReviewStatus

5/5

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Depolymerization of lamin filaments after PKC-mediated phosphorylation

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Protein kinase C (PRKCA and PRKCB), activated by lipin-generated diacylglycerol (DAG), phosphorylates C-terminal tails of lamins (serine S395 in lamins A, B and C, and also serine S405 of lamin B), leading to depolymerization of lamin filaments (Hocevar et al. 1993, Goss et al. 1994, Mall et al. 2012).

Literature References

PubMed ID	Title	Journal	Year
22986494	Mitotic lamin disassembly is triggered by lipid-mediated signaling Mall, M, Davidson, IF, Walter, T, Ellenberg, J, Nga Ly-Hartig, TB, Mattaj, IW, Gorjánácz, M	J. Cell Biol.	2012
8034666	Identification of nuclear beta II protein kinase C as a mitotic lamin kinase Thompson, LJ, Burns, DJ, Hocevar, BA, Stratton, CA, Goss, VL, Fields, AP	J. Biol. Chem.	1994
8463284	Identification of protein kinase C (PKC) phosphorylation sites on human lamin B. Potential role of PKC in nuclear lamina structural dynamics Burns, DJ, Hocevar, BA, Fields, AP	J. Biol. Chem.	1993