Depolymerization of lamin filaments after PKC-mediated phosphorylation

Stable Identifier
Reaction [transition]
Homo sapiens
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Protein kinase C (PRKCA and PRKCB), activated by lipin-generated diacylglycerol (DAG), phosphorylates C-terminal tails of lamins (serine S395 in lamins A, B and C, and also serine S405 of lamin B), leading to depolymerization of lamin filaments (Hocevar et al. 1993, Goss et al. 1994, Mall et al. 2012).

Literature References
PubMed ID Title Journal Year
22986494 Mitotic lamin disassembly is triggered by lipid-mediated signaling

Mall, M, Davidson, IF, Walter, T, Ellenberg, J, Nga Ly-Hartig, TB, Mattaj, IW, Gorjánácz, M

J. Cell Biol. 2012
8034666 Identification of nuclear beta II protein kinase C as a mitotic lamin kinase

Thompson, LJ, Burns, DJ, Hocevar, BA, Stratton, CA, Goss, VL, Fields, AP

J. Biol. Chem. 1994
8463284 Identification of protein kinase C (PKC) phosphorylation sites on human lamin B. Potential role of PKC in nuclear lamina structural dynamics

Burns, DJ, Hocevar, BA, Fields, AP

J. Biol. Chem. 1993
Catalyst Activity

protein kinase C activity of DAG:active PKC:Ca+2 [nuclear envelope]

Orthologous Events
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