CDK8 phosphorylates NICD1 PEST domain mutants

Stable Identifier
R-HSA-2220971
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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CDK8 phosphorylates NICD1 PEST domain mutants
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While CDK8 can probably phosphorylate the TAD domain of NICD1 PEST domain mutants, it cannot phosphorylate the PEST domain of these mutants as it is partially or completely truncated (Fryer et al. 2004).
Literature References
PubMed ID Title Journal Year
15546612 Mastermind recruits CycC:CDK8 to phosphorylate the Notch ICD and coordinate activation with turnover

Fryer, CJ, Jones, KA, White, JB

Mol Cell 2004
Participants
Input
Output
Participates
as an event of
Catalyst Activity

cyclin-dependent protein serine/threonine kinase activity of NOTCH1 PEST Domain Mutants Coactivator Complex:CDK8:CCNC [nucleoplasm]

Physical Entity
NOTCH1 PEST Domain Mutants Coactivator Complex:CDK8:CCNC [nucleoplasm] (Homo sapiens)
Activity
cyclin-dependent protein serine/threonine kinase activity (GO:0004693)
Normal reaction
NICD1 is phosphorylated by CDK8 (Homo sapiens)
Functional status

Gain of function of NOTCH1 PEST Domain Mutants Coactivator Complex:CDK8:CCNC [nucleoplasm]

Normal Entity
Disease Entity
Status
Disease
Name Identifier Synonyms
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
T-cell acute lymphoblastic leukemia DOID:5603
Authored
Orlic-Milacic, M  (2013-01-04)
Reviewed
Haw, R  (2013-02-10)
Created
Orlic-Milacic, M  (2012-05-03)
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