Phosphorylation of Cyclin D1 at T286 by glycogen synthase kinase-3 beta

Stable Identifier
R-HSA-75820
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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Phosphorylation of Cyclin D1 at T286 by glycogen synthase kinase-3 beta
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
At the beginning of this reaction, 1 molecule of 'Cyclin D1:Cdk4', and 1 molecule of 'ATP' are present. At the end of this reaction, 1 molecule of 'phospho(T286)-Cyclin D1:Cdk4', and 1 molecule of 'ADP' are present.

This reaction takes place in the 'nucleus' and is mediated by the 'kinase activity' of 'glycogen synthase kinase-3 beta'.
Literature References
PubMed ID Title Journal Year
16732330 Identification of mutations that disrupt phosphorylation-dependent nuclear export of cyclin D1

Benzeno, S, Lu, F, Guo, M, Barbash, O, Zhang, F, Herman, JG, Klein, PS, Rustgi, A, Diehl, JA

Oncogene 2006
Participants
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Output
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as an event of
Catalyst Activity

protein serine/threonine kinase activity of GSK3B [nucleoplasm]

Physical Entity
GSK3B [nucleoplasm] (Homo sapiens)
Activity
protein serine/threonine kinase activity (GO:0004674)
Inferred From
Phosphorylation of Cyclin D1 on Thr-286 by GSK-3 beta (Mus musculus)
Created
Matthews, L  (2003-09-01)
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