Reactome | CAMK4 autophosphorylates

CAMK4 autophosphorylates

Stable Identifier

R-HSA-111915

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

Locations in the PathwayBrowser

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Neuronal System (Homo sapiens)

- Transmission across Chemical Synapses (Homo sapiens)
  - Neurotransmitter receptors and postsynaptic signal transmission (Homo sapiens)
    - Activation of NMDA receptors and postsynaptic events (Homo sapiens)
      - Post NMDA receptor activation events (Homo sapiens)
        
        CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde (Homo sapiens)
        
        CAMK4 autophosphorylates (Homo sapiens)

Signal Transduction (Homo sapiens)

- Intracellular signaling by second messengers (Homo sapiens)
  - DAG and IP3 signaling (Homo sapiens)
    - CaM pathway (Homo sapiens)
      - Calmodulin induced events (Homo sapiens)
        
        CaMK IV-mediated phosphorylation of CREB (Homo sapiens)
        
        CAMK4 autophosphorylates (Homo sapiens)
- Signaling by GPCR (Homo sapiens)
  - GPCR downstream signalling (Homo sapiens)
    - G alpha (i) signalling events (Homo sapiens)
      - Opioid Signalling (Homo sapiens)
        
        G-protein mediated events (Homo sapiens)
        
        PLC beta mediated events (Homo sapiens)
        
        Ca-dependent events (Homo sapiens)
        
        CaM pathway (Homo sapiens)
        
        Calmodulin induced events (Homo sapiens)
        
        CaMK IV-mediated phosphorylation of CREB (Homo sapiens)
        
        CAMK4 autophosphorylates (Homo sapiens)

General

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Autophosphorylation of the N-terminal serine residues, S12 and S13, of CAMK4 is required for full activation after Ca2+/calmodulin binding and phosphorylation of the Ca2+/calmodulin-bound enzyme on threonine residue T200 by a Ca2+/calmodulin-dependent protein kinase kinase (CAMKK1 or CAMKK2) (Chatila et al. 1996).

Literature References

PubMed ID	Title	Journal	Year
8702940	A unique phosphorylation-dependent mechanism for the activation of Ca2+/calmodulin-dependent protein kinase type IV/GR Chatila, T, Anderson, KA, Ho, N, Means, AR	J Biol Chem	1996

Participants

Input

Output

Participant Of

hasEvent

Catalyst Activity

Title

calmodulin-dependent protein kinase activity of p-T200-CAMK4:CALM1:4xCa2+ [nucleoplasm]

Physical Entity

p-T200-CAMK4:CALM1:4xCa2+ [nucleoplasm]

Activity

calmodulin-dependent protein kinase activity (0004683)

Orthologous Events

CAMK4 autophosphorylates (Bos taurus)

CAMK4 autophosphorylates (Canis familiaris)

CAMK4 autophosphorylates (Dictyostelium discoideum)

CAMK4 autophosphorylates (Drosophila melanogaster)

CAMK4 autophosphorylates (Mus musculus)

CAMK4 autophosphorylates (Plasmodium falciparum)

CAMK4 autophosphorylates (Rattus norvegicus)

CAMK4 autophosphorylates (Saccharomyces cerevisiae)

CAMK4 autophosphorylates (Xenopus tropicalis)

Authored

Le Novere, N (2004-03-31)

Jassal, B (2004-03-31)

Reviewed

Castagnoli, L (2008-11-06)

Yi, F (2018-11-02)

Hansen, KB (2018-11-02)

Created

Schmidt, EE (2004-03-25)