Autophosphorylation of the N-terminal serine residues, S12 and S13, of CAMK4 is required for full activation after Ca2+/calmodulin binding and phosphorylation of the Ca2+/calmodulin-bound enzyme on threonine residue T200 by a Ca2+/calmodulin-dependent protein kinase kinase (CAMKK1 or CAMKK2) (Chatila et al. 1996).
Ho, N, Anderson, KA, Means, AR, Chatila, T
calmodulin-dependent protein kinase activity of p-T200-CAMK4:CALM1:4xCa2+ [nucleoplasm]
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