ATM phosphorylates RBBP8

Stable Identifier
R-HSA-5684140
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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CDK2-mediated phosphorylation of RBBP8 (CtIP) triggers ATM-mediated phosphorylation of RBBP8 on several ATM consensus SQ/TQ sites. The ATM phosphorylation site at threonine residue T859 of RBBP8 is evolutionarily conserved and seems to be particularly important for the RBBP8-promoted resection of DNA double strand break (DSB) ends (Wang et al. 2013).

Literature References
PubMed ID Title Journal Year
23468639 The interaction of CtIP and Nbs1 connects CDK and ATM to regulate HR-mediated double-strand break repair

Wang, H, Shi, LZ, Wong, CC, Han, X, Hwang, PY, Truong, LN, Zhu, Q, Shao, Z, Chen, DJ, Berns, MW, Yates, JR, Chen, L, Wu, X

PLoS Genet. 2013
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine kinase activity of DNA DSBs:p-MRN:p-S327,T847-RBBP8:p-S1981,Ac-K3016-ATM:KAT5 [nucleoplasm]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created