PKCalpha phosphorylates HuR

Stable Identifier
R-HSA-450550
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
PKCalpha phosphorylates HuR
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Protein kinase C alpha (PKCalpha) phosphorylates HuR (ELAVL1) on serine221 and serine 158.
Literature References
PubMed ID Title Journal Year
17392515 Protein kinase C alpha-dependent phosphorylation of the mRNA-stabilizing factor HuR: implications for posttranscriptional regulation of cyclooxygenase-2

Pfeilschifter, J, Müller, R, Doller, A, Huwiler, A, Eberhardt, W, Radeke, HH

Mol Biol Cell 2007
Participants
Input
Output
Participates
as an event of
Catalyst Activity

diacylglycerol-dependent serine/threonine kinase activity of PRKCA [nucleoplasm]

Physical Entity
PRKCA [nucleoplasm] (Homo sapiens)
Activity
diacylglycerol-dependent serine/threonine kinase activity (GO:0004697)
Orthologous Events
PKCalpha phosphorylates HuR (Canis familiaris)
PKCalpha phosphorylates HuR (Drosophila melanogaster)
PKCalpha phosphorylates HuR (Gallus gallus)
PKCalpha phosphorylates HuR (Mus musculus)
PKCalpha phosphorylates HuR (Rattus norvegicus)
PKCalpha phosphorylates HuR (Sus scrofa)
Authored
May, B  (2009-12-29)
Reviewed
Wilusz, J  (2010-06-29)
Created
May, B  (2009-12-17)
Cite Us!