AMPK phosphorylates PPARGC1A

Stable Identifier
R-HSA-1592244
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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AMPK phosphorylates PPARGC1A
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As inferred from mouse, AMPK is activated by AMP and phosphorylates PGC-1alpha (PPARGC1A). It is hypothesized that this reaction connects energy depletion (low ATP, high AMP) to mitochondrial biogenesis (activation of PGC-1alpha).
Literature References
PubMed ID Title Journal Year
21451146 An acute bout of high-intensity interval training increases the nuclear abundance of PGC-1? and activates mitochondrial biogenesis in human skeletal muscle

Little, JP, Gibala, MJ, Tarnopolsky, MA, Bishop, D, Safdar, A

Am J Physiol Regul Integr Comp Physiol 2011
19112161 Brief intense interval exercise activates AMPK and p38 MAPK signaling and increases the expression of PGC-1alpha in human skeletal muscle

McGee, SL, Gibala, MJ, Hargreaves, M, Howlett, KF, Garnham, AP, Snow, RJ

J Appl Physiol 2009
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Catalyst Activity

AMP-activated protein kinase activity of p-AMPK heterotrimer:AMP [nucleoplasm]

Physical Entity
p-AMPK heterotrimer:AMP [nucleoplasm] (Homo sapiens)
Activity
AMP-activated protein kinase activity (GO:0004679)
Inferred From
Ampk phosphorylates Ppargc1a (Mus musculus)
Authored
May, B  (2011-08-20)
Reviewed
Lezza, AM  (2013-12-07)
Created
May, B  (2011-09-09)
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