ATM phosphorylates DYRK2

Stable Identifier
R-HSA-6798372
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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ATM phosphorylates DYRK2
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Activated ATM kinase phosphorylates DYRK2 at threonine residue T106 (matching T33 in the shorter splicing isoform of DYRK2) and serine residue S442 (matching S369 in the shorter splicing isoform of DYRK2). ATM-mediated phosphorylation of DYRK2 prevents DYRK2 ubiquitination by MDM2 and the consequent DYRK2 degradation (Taira et al. 2010).
Literature References
PubMed ID Title Journal Year
19965871 ATM augments nuclear stabilization of DYRK2 by inhibiting MDM2 in the apoptotic response to DNA damage

Taira, N, Yamamoto, H, Yamaguchi, T, Miki, Y, Yoshida, K

J. Biol. Chem. 2010
Participants
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Output
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as an event of
Catalyst Activity

protein serine/threonine kinase activity of p-S1981,Ac-K3016-ATM [nucleoplasm]

Physical Entity
p-S1981,Ac-K3016-ATM [nucleoplasm] (Homo sapiens)
Activity
protein serine/threonine kinase activity (GO:0004674)
Orthologous Events
ATM phosphorylates DYRK2 (Bos taurus)
ATM phosphorylates DYRK2 (Canis familiaris)
ATM phosphorylates DYRK2 (Danio rerio)
ATM phosphorylates DYRK2 (Dictyostelium discoideum)
ATM phosphorylates DYRK2 (Drosophila melanogaster)
ATM phosphorylates DYRK2 (Gallus gallus)
ATM phosphorylates DYRK2 (Mus musculus)
ATM phosphorylates DYRK2 (Rattus norvegicus)
ATM phosphorylates DYRK2 (Schizosaccharomyces pombe)
ATM phosphorylates DYRK2 (Sus scrofa)
Authored
Orlic-Milacic, M  (2015-10-14)
Reviewed
Zaccara, S  (2016-02-04)
Inga, A  (2016-02-04)
Created
Orlic-Milacic, M  (2015-09-19)
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