ATM phosphorylates DYRK2

Stable Identifier
R-HSA-6798372
Type
Reaction
Species
Homo sapiens
Compartment
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Activated ATM kinase phosphorylates DYRK2 at threonine residue T106 (matching T33 in the shorter splicing isoform of DYRK2) and serine residue S442 (matching S369 in the shorter splicing isoform of DYRK2). ATM-mediated phosphorylation of DYRK2 prevents DYRK2 ubiquitination by MDM2 and the consequent DYRK2 degradation (Taira et al. 2010).

Literature References
PubMed ID Title Journal Year
19965871 ATM augments nuclear stabilization of DYRK2 by inhibiting MDM2 in the apoptotic response to DNA damage

Yamamoto, H, Miki, Y, Taira, N, Yoshida, K, Yamaguchi, T

J. Biol. Chem. 2010
Participants
Participates
Catalyst Activity

protein serine/threonine kinase activity of p-S1981,Ac-K3016-ATM [nucleoplasm]

Orthologous Events
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