AKT phosphorylation of the pro-apoptotic Forkhead transcription factor FOXO3 and other Foxo family members occurs downstream of FLT3 and FLT3-ITD-mediated signaling (Scheijen et al, 2004; Brandts et al 2005; reviewed in Kazi and Roonstrand, 2019). AKT-mediated phosphorylation promotes nuclear export, resulting in a decrease in expression of apoptosis-promoting FOXO3-target genes (Brunet et al, 1999; reviewed in Burgering, 2008; Yadav et al, 2018).
Hu, LS, Bonni, A, Brunet, A, Blenis, J, Zigmond, MJ, Anderson, MJ, Lin, MZ, Greenberg, ME, Juo, P, Arden, KC
Kazi, JU, Rönnstrand, L
Zhuang, L, Yadav, RK, Chauhan, AS, Gan, B
Burgering, BM
Griffin, JD, Scheijen, B, Kang, H, Ngo, HT
Berdel, WE, Serve, H, Rode, M, Brandts, CH, Sargin, B, Buerger, H, McMahon, M, Choudhary, C, Biermann, C, Lindtner, B, Müller-Tidow, C, Schwäble, J
protein serine/threonine kinase activity of p-T,p-S-AKT [nucleoplasm]
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