AKT phosphorylation of the pro-apoptotic Forkhead transcription factor FOXO3 and other Foxo family members occurs downstream of FLT3 and FLT3-ITD-mediated signaling (Scheijen et al, 2004; Brandts et al 2005; reviewed in Kazi and Roonstrand, 2019). AKT-mediated phosphorylation promotes nuclear export, resulting in a decrease in expression of apoptosis-promoting FOXO3-target genes (Brunet et al, 1999; reviewed in Burgering, 2008; Yadav et al, 2018).
Kazi, JU, Rönnstrand, L
Brunet, A, Bonni, A, Zigmond, MJ, Lin, MZ, Juo, P, Hu, LS, Anderson, MJ, Arden, KC, Blenis, J, Greenberg, ME
Yadav, RK, Chauhan, AS, Zhuang, L, Gan, B
Burgering, BM
Scheijen, B, Ngo, HT, Kang, H, Griffin, JD
Brandts, CH, Sargin, B, Rode, M, Biermann, C, Lindtner, B, Schwäble, J, Buerger, H, Müller-Tidow, C, Choudhary, C, McMahon, M, Berdel, WE, Serve, H
© 2021 Reactome
