AKT phosphorylates FOXO3 downstream of FLT3

Stable Identifier
R-HSA-9699579
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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AKT phosphorylation of the pro-apoptotic Forkhead transcription factor FOXO3 and other Foxo family members occurs downstream of FLT3 and FLT3-ITD-mediated signaling (Scheijen et al, 2004; Brandts et al 2005; reviewed in Kazi and Roonstrand, 2019). AKT-mediated phosphorylation promotes nuclear export, resulting in a decrease in expression of apoptosis-promoting FOXO3-target genes (Brunet et al, 1999; reviewed in Burgering, 2008; Yadav et al, 2018).

Literature References
PubMed ID Title Journal Year
14981546 FLT3 receptors with internal tandem duplications promote cell viability and proliferation by signaling through Foxo proteins

Griffin, JD, Scheijen, B, Kang, H, Ngo, HT

Oncogene 2004
10102273 Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor

Hu, LS, Bonni, A, Brunet, A, Blenis, J, Zigmond, MJ, Anderson, MJ, Lin, MZ, Greenberg, ME, Juo, P, Arden, KC

Cell 1999
31066629 FMS-like Tyrosine Kinase 3/FLT3: From Basic Science to Clinical Implications

Kazi, JU, Rönnstrand, L

Physiol. Rev. 2019
18391968 A brief introduction to FOXOlogy

Burgering, BM

Oncogene 2008
29309929 FoxO transcription factors in cancer metabolism

Zhuang, L, Yadav, RK, Chauhan, AS, Gan, B

Semin. Cancer Biol. 2018
16266983 Constitutive activation of Akt by Flt3 internal tandem duplications is necessary for increased survival, proliferation, and myeloid transformation

Berdel, WE, Serve, H, Rode, M, Brandts, CH, Sargin, B, Buerger, H, McMahon, M, Choudhary, C, Biermann, C, Lindtner, B, Müller-Tidow, C, Schwäble, J

Cancer Res. 2005
Participants
Participates
Catalyst Activity

protein serine/threonine kinase activity of p-T,p-S-AKT [nucleoplasm]

Orthologous Events
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