Phosphorylation of ChREBP at Serine 568 by AMPK

Stable Identifier
R-HSA-163691
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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In the nucleus, activated AMPK phosphorylates serine residue 568 of ChREBP (Carbohydrate Response Element Binding Protein). Phosphorylated ChREBP does not bind to ChRE chromosomal DNA sequence elements and thus loses its ability to promote transcription of genes involved in glycolysis and lipogenesis.

Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
AMP-activated protein kinase activity of Activated AMPK heterotrimer [nucleoplasm]
Physical Entity
Activity
This event is regulated
Negatively by
Inferred From
Authored
Created