Reactome | p-T68-CHEK2 autophosphorylates

p-T68-CHEK2 autophosphorylates

Stable Identifier

R-HSA-5683792

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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Upon dimerization, p-T68-CHEK2 protomers trans-autophosphorylate on serine residue S379 (Lovly et al. 2008) and threonine residues T383 and T387 (Lee et al. 2001). Autophosphorylation leads to dissociation of CHEK2 dimers into active CHEK2 monomers (Cai et al. 2009).

Literature References

PubMed ID	Title	Journal	Year
19782031	Structure and activation mechanism of the CHK2 DNA damage checkpoint kinase Cai, Z, Chehab, NH, Pavletich, NP	Mol. Cell	2009
18644861	Regulation of Chk2 ubiquitination and signaling through autophosphorylation of serine 379 Lovly, CM, Yan, L, Ryan, CE, Takada, S, Piwnica-Worms, H	Mol. Cell. Biol.	2008
11390408	The hCds1 (Chk2)-FHA domain is essential for a chain of phosphorylation events on hCds1 that is induced by ionizing radiation Lee, CH, Chung, JH	J. Biol. Chem.	2001