MAPK1 phosphorylates SOX10

Stable Identifier
R-HSA-9824582
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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SOX10 is phosphorylated by MAPK1 (ERK2) at threonine residues T240 and T244. Phosphorylation inhibits SOX10 transcriptional activity and its ability to activate MITF, possibly by inhibiting the sumoylation of SOX10 at K55 by UBE2I (UBC9) as has been shown for the FOXD3 promoter (Han et al, 2018). Consistent with this, MAPK/ERK inhibition induces SOX10 recruitment to MITF regulatory regions (Fufa et al, 2019).
Literature References
PubMed ID Title Journal Year
31399133 MEK inhibition remodels the active chromatin landscape and induces SOX10 genomic recruitment in BRAF(V600E) mutant melanoma cells

Fufa, TD, Baxter, LL, Wedel, JC, Gildea, DE, NISC Comparative Sequencing Program, -, Loftus, SK, Pavan, WJ

Epigenetics Chromatin 2019
29295999 ERK-mediated phosphorylation regulates SOX10 sumoylation and targets expression in mutant BRAF melanoma

Han, S, Ren, Y, He, W, Liu, H, Zhi, Z, Zhu, X, Yang, T, Rong, Y, Ma, B, Purwin, TJ, Ouyang, Z, Li, C, Wang, X, Wang, X, Yang, H, Zheng, Y, Aplin, AE, Liu, J, Shao, Y

Nat Commun 2018
Participants
Participates
Catalyst Activity

protein serine/threonine kinase activity of p-T185,Y187 MAPK1 dimer [cytosol]

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