ERKs phosphorylate MCRIP1

Stable Identifier
R-HSA-9765960
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
3/5
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ERKs phosphorylate MCRIP1
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Activated MAPKs (ERKs) phosphorylate MCRIP1 on conserved residues serine 21 (S21) and threonine 30 (T30), which negatively impacts binding of MCRIP1 to CTBP1 (Ichikawa et al. 2015).
Literature References
PubMed ID Title Journal Year
25728771 MCRIP1, an ERK substrate, mediates ERK-induced gene silencing during epithelial-mesenchymal transition by regulating the co-repressor CtBP

Ichikawa, K, Kubota, Y, Nakamura, T, Weng, JS, Tomida, T, Saito, H, Takekawa, M

Mol Cell 2015
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Output
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as an event of
Catalyst Activity

protein serine/threonine kinase activity of p-T,Y MAPK monomers and dimers [nucleoplasm]

Physical Entity
p-T,Y MAPK monomers and dimers [nucleoplasm] (Homo sapiens)
Activity
protein serine/threonine kinase activity (GO:0004674)
Authored
Orlic-Milacic, M  (2022-02-17)
Created
Orlic-Milacic, M  (2022-02-17)
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