Activated ATM phosphorylates CHEK2 (CHK2, Cds1) on threonine residue T68 (Matsuoka et al. 2000, Melchionna et al. 2000). The presence of BRCA1 and TP53BP1 positively regulates ATM-mediated phosphorylation of CHEK2 (Wang et al. 2002, Foray et al. 2003). ATM-mediated phosphorylation causes formation of CHEK2 dimers and dissociation of CHEK2 from chromatin (Li and Stern 2005).
Li, J, Stern, DF
Melchionna, R, Chen, XB, Blasina, A, McGowan, CH
Wang, B, Matsuoka, S, Carpenter, PB, Elledge, SJ
Matsuoka, S, Rotman, G, Ogawa, A, Shiloh, Y, Tamai, K, Elledge, SJ
Foray, N, Marot, D, Gabriel, A, Randrianarison, V, Perricaudet, M, Ashworth, A, Jeggo, P
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