Reactome | Phosphorylation and activation of CHEK2 by ATM

Phosphorylation and activation of CHEK2 by ATM

Stable Identifier

R-HSA-69891

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

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Phosphorylation and activation of CHEK2 by ATM

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Activated ATM phosphorylates CHEK2 (CHK2, Cds1) on threonine residue T68 (Matsuoka et al. 2000, Melchionna et al. 2000). The presence of BRCA1 and TP53BP1 positively regulates ATM-mediated phosphorylation of CHEK2 (Wang et al. 2002, Foray et al. 2003). ATM-mediated phosphorylation causes formation of CHEK2 dimers and dissociation of CHEK2 from chromatin (Li and Stern 2005).

Literature References

PubMed ID	Title	Journal	Year
16150728	DNA damage regulates Chk2 association with chromatin Li, J, Stern, DF	J. Biol. Chem.	2005
11025670	Threonine 68 is required for radiation-induced phosphorylation and activation of Cds1 Melchionna, R, Chen, XB, Blasina, A, McGowan, CH	Nat. Cell Biol.	2000
12364621	53BP1, a mediator of the DNA damage checkpoint. Wang, B, Matsuoka, S, Carpenter, PB, Elledge, SJ	Science	2002
10973490	Ataxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitro Matsuoka, S, Rotman, G, Ogawa, A, Shiloh, Y, Tamai, K, Elledge, SJ	Proc Natl Acad Sci U S A	2000
12773400	A subset of ATM- and ATR-dependent phosphorylation events requires the BRCA1 protein. Foray, N, Marot, D, Gabriel, A, Randrianarison, V, Perricaudet, M, Ashworth, A, Jeggo, P	EMBO J	2003

Participants

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Output

Participant Of

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Catalyst Activity

Title

protein serine/threonine kinase activity of DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex:CHEK2 [nucleoplasm]

Physical Entity

DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex:CHEK2 [nucleoplasm]

Activity

protein serine/threonine kinase activity (0004674)

Orthologous Events

Phosphorylation and activation of CHEK2 by ATM (Canis familiaris)

Phosphorylation and activation of CHEK2 by ATM (Danio rerio)

Phosphorylation and activation of CHEK2 by ATM (Gallus gallus)

Phosphorylation and activation of CHEK2 by ATM (Mus musculus)

Phosphorylation and activation of CHEK2 by ATM (Rattus norvegicus)

Phosphorylation and activation of CHEK2 by ATM (Sus scrofa)

Phosphorylation and activation of CHEK2 by ATM (Xenopus tropicalis)