MSH2:MSH3 exchanges ADP for ATP

Stable Identifier
R-HSA-5358919
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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MSH2:MSH3 exchanges ADP for ATP
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After binding a mismatch, the MSH2:MSH3 (MutSbeta) heterodimer exchanges ADP for ATP, which changes the conformation of MSH2:MSH3 to a sliding clamp or molecular switch able to diffuse in one direction along duplex DNA (Gu et al. 1998, Zhang et al. 2005, and inferred from MSH2:MSH6).
Literature References
PubMed ID Title Journal Year
16143102 Reconstitution of 5'-directed human mismatch repair in a purified system

Zhang, Y, Yuan, F, Presnell, SR, Tian, K, Gao, Y, Tomkinson, AE, Gu, L, Li, GM

Cell 2005
9469823 ATP-dependent interaction of human mismatch repair proteins and dual role of PCNA in mismatch repair

Gu, L, Hong, Y, McCulloch, S, Watanabe, H, Li, GM

Nucleic Acids Res. 1998
Participants
Input
Output
Participates
as an event of
Inferred From
MSH2:MSH6 exchanges ADP for ATP (Homo sapiens)
Authored
May, B  (2014-03-28)
Reviewed
Edelbrock, MA  (2014-05-23)
Created
May, B  (2014-04-05)
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