MSH2:MSH3 exchanges ADP for ATP

Stable Identifier
R-HSA-5358919
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
MSH2:MSH3 exchanges ADP for ATP
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

After binding a mismatch, the MSH2:MSH3 (MutSbeta) heterodimer exchanges ADP for ATP, which changes the conformation of MSH2:MSH3 to a sliding clamp or molecular switch able to diffuse in one direction along duplex DNA (Gu et al. 1998, Zhang et al. 2005, and inferred from MSH2:MSH6).

Literature References
PubMed ID Title Journal Year
16143102 Reconstitution of 5'-directed human mismatch repair in a purified system

Gao, Y, Zhang, Y, Li, GM, Yuan, F, Tian, K, Presnell, SR, Gu, L, Tomkinson, AE

Cell 2005
9469823 ATP-dependent interaction of human mismatch repair proteins and dual role of PCNA in mismatch repair

Watanabe, H, Li, GM, McCulloch, S, Gu, L, Hong, Y

Nucleic Acids Res. 1998
Participants
Input
Output
Participates
as an event of
Inferred From
MSH2:MSH6 exchanges ADP for ATP (Homo sapiens)
Authored
May, B  (2014-03-28)
Reviewed
Edelbrock, MA  (2014-05-23)
Created
May, B  (2014-04-05)
Cite Us!