MSH2:MSH3 exchanges ADP for ATP

Stable Identifier
R-HSA-5358919
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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MSH2:MSH3 exchanges ADP for ATP
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After binding a mismatch, the MSH2:MSH3 (MutSbeta) heterodimer exchanges ADP for ATP, which changes the conformation of MSH2:MSH3 to a sliding clamp or molecular switch able to diffuse in one direction along duplex DNA (Gu et al. 1998, Zhang et al. 2005, and inferred from MSH2:MSH6).
Literature References
PubMed ID Title Journal Year
16143102 Reconstitution of 5'-directed human mismatch repair in a purified system

Gao, Y, Zhang, Y, Li, GM, Yuan, F, Tian, K, Presnell, SR, Gu, L, Tomkinson, AE

Cell 2005
9469823 ATP-dependent interaction of human mismatch repair proteins and dual role of PCNA in mismatch repair

Watanabe, H, Li, GM, McCulloch, S, Gu, L, Hong, Y

Nucleic Acids Res. 1998
Participants
Input
Output
Participates
as an event of
Inferred From
MSH2:MSH6 exchanges ADP for ATP (Homo sapiens)
Authored
May, B  (2014-03-28)
Reviewed
Edelbrock, MA  (2014-05-23)
Created
May, B  (2014-04-05)
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