Reactome | MRN bound to shortened telomeres activates ATM

MRN bound to shortened telomeres activates ATM

Stable Identifier

R-HSA-5682026

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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MRN bound to shortened telomeres activates ATM

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MRN bound to shortened telomeres promotes dissociation of ATM dimers to ATM monomers which is accompanied by ATM autophosphorylation on serine residue S1981. Dissociation of ATM dimers requires the ATP-dependent DNA-helicase activity of the MRN subunit RAD50 (Lee and Paull 2005, Wu et al. 2007).

Literature References

PubMed ID	Title	Journal	Year
15790808	ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex Paull, TT, Lee, JH	Science	2005
17694070	MRE11-RAD50-NBS1 and ATM function as co-mediators of TRF1 in telomere length control Xiao, S, Wu, Y, Zhu, XD	Nat. Struct. Mol. Biol.	2007