(CDK1,CDK2):CCNA phosphorylates MDM2 at T218

Stable Identifier
R-HSA-6793661
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
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(CDK1,CDK2):CCNA phosphorylates MDM2 at T218
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CDK1 or CDK2 in complex with CCNA (cyclin A) phosphorylates MDM2 at threonine residue T218. Phosphorylation of MDM2 at T218 increases its affinity for p14-ARF and reduces its affinity for TP53 (p53), thus resulting in TP53 upregulation (Zhang and Prives 2001).

Literature References
PubMed ID Title Journal Year
11359766 Cyclin a-CDK phosphorylation regulates MDM2 protein interactions

Zhang, T, Prives, C

J. Biol. Chem. 2001
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
cyclin-dependent protein serine/threonine kinase activity of CCNA:p-CDK1/2 [nucleoplasm]
Physical Entity
CCNA:p-CDK1/2 [nucleoplasm]
Activity
cyclin-dependent protein serine/threonine kinase activity (0004693)
Orthologous Events
(CDK1,CDK2):CCNA phosphorylates MDM2 at T218 (Bos taurus)
(CDK1,CDK2):CCNA phosphorylates MDM2 at T218 (Caenorhabditis elegans)
(CDK1,CDK2):CCNA phosphorylates MDM2 at T218 (Canis familiaris)
(CDK1,CDK2):CCNA phosphorylates MDM2 at T218 (Gallus gallus)
(CDK1,CDK2):CCNA phosphorylates MDM2 at T218 (Mus musculus)
(CDK1,CDK2):CCNA phosphorylates MDM2 at T218 (Rattus norvegicus)
(CDK1,CDK2):CCNA phosphorylates MDM2 at T218 (Sus scrofa)
(CDK1,CDK2):CCNA phosphorylates MDM2 at T218 (Xenopus tropicalis)
Authored
Orlic-Milacic, M  (2015-10-14)
Reviewed
Zaccara, S  (2016-02-04)
Inga, A  (2016-02-04)
Created
Orlic-Milacic, M  (2015-09-03)