CDK1 or CDK2 in complex with CCNA (cyclin A) phosphorylates MDM2 at threonine residue T218. Phosphorylation of MDM2 at T218 increases its affinity for p14-ARF and reduces its affinity for TP53 (p53), thus resulting in TP53 upregulation (Zhang and Prives 2001).
Zhang, T, Prives, C
cyclin-dependent protein serine/threonine kinase activity of CCNA:p-CDK1/2 [nucleoplasm]
© 2022 Reactome