CDK2:CCNA phosphorylates TERF2

Stable Identifier
R-HSA-9686521
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Outside of the S phase of the cell cycle, the shelterin complex subunit TERF2 (TRF2) is phosphorylated on serine residue S365. This phosphorylation is performed by the complex of CDK2 and cyclin A (CCNA). Phosphorylation of TERF2 at S365 prevents association of RTEL1 with telomeres, thus protecting t-loops from promiscuous unwinding and inappropriate activation of ATM (Sarek et al. 2019).

Literature References
PubMed ID Title Journal Year
31723267 CDK phosphorylation of TRF2 controls t-loop dynamics during the cell cycle

Sarek, G, Kotsantis, P, Ruis, P, Van Ly, D, Margalef, P, Borel, V, Zheng, XF, Flynn, HR, Snijders, AP, Chowdhury, D, Cesare, AJ, Boulton, SJ

Nature 2019
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
cyclin-dependent protein serine/threonine kinase activity of CCNA:p-T160-CDK2 [nucleoplasm]
Physical Entity
Activity
Orthologous Events
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Created
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