CAK-mediated phosphorylation of Cyclin B1:Cdc2 complexes

Stable Identifier
R-HSA-170076
Type
Reaction
Species
Homo sapiens
Compartment
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Full activity of most CDKs is dependent on CAK mediated phosphorylation at a conserved residue (Thr161 in Cdc2). This modification is thought to improve substrate binding. Cyclin B:Cdc2 complexes have considerably low activity in the absence of CAK mediated phosphorylation (Desai et al 1995).

Literature References
PubMed ID Title Journal Year
7799941 Effects of phosphorylation by CAK on cyclin binding by CDC2 and CDK2.

Wessling, HC, Desai, D, Fisher, RP, Morgan, DO

Mol Cell Biol 1995
Participants
Participates
Catalyst Activity

protein serine/threonine kinase activity of CAK [nucleoplasm]

Orthologous Events
Created
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