ABL1 phosphorylates YAP1

Stable Identifier
R-HSA-8956659
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
ABL1 phosphorylates YAP1
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
In response to DNA damage, ABL1 phosphorylates YAP1 on tyrosine residue Y407 (corresponds to Y357 in the YAP1 splicing isoform 3, known as YAP1-1beta, which was used in the study by Levy, Adamovich et al. 2008).
Literature References
PubMed ID Title Journal Year
18280240 Yap1 phosphorylation by c-Abl is a critical step in selective activation of proapoptotic genes in response to DNA damage

Shaul, Y, Reuven, N, Adamovich, Y, Levy, D

Mol. Cell 2008
Participants
Input
Output
Participates
as an event of
Catalyst Activity

protein tyrosine kinase activity of p-S456-ABL1 [nucleoplasm]

Physical Entity
p-S456-ABL1 [nucleoplasm] (Homo sapiens)
Activity
protein tyrosine kinase activity (GO:0004713)
Orthologous Events
ABL1 phosphorylates YAP1 (Bos taurus)
ABL1 phosphorylates YAP1 (Caenorhabditis elegans)
ABL1 phosphorylates YAP1 (Canis familiaris)
ABL1 phosphorylates YAP1 (Gallus gallus)
ABL1 phosphorylates YAP1 (Mus musculus)
ABL1 phosphorylates YAP1 (Rattus norvegicus)
ABL1 phosphorylates YAP1 (Sus scrofa)
ABL1 phosphorylates YAP1 (Xenopus tropicalis)
Authored
Orlic-Milacic, M  (2016-09-14)
Reviewed
Chuang, LS  (2016-12-20)
Ito, Y  (2016-12-20)
Created
Orlic-Milacic, M  (2017-01-24)
Cite Us!