Reactome | BACH1 is phosphorylated at tyrosine 483

BACH1 is phosphorylated at tyrosine 483

Stable Identifier

R-HSA-9762209

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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BACH1 is phosphorylated by an unknown kinase within 1-2 hours of antioxidant treatment, prompting its nuclear export (Ishikawa et al, 2005; Kaspar and Jaiswal, 2010).

Literature References

PubMed ID	Title	Journal	Year
19897490	Antioxidant-induced phosphorylation of tyrosine 486 leads to rapid nuclear export of Bach1 that allows Nrf2 to bind to the antioxidant response element and activate defensive gene expression Kaspar, JW, Jaiswal, AK	J Biol Chem	2010
15855052	Redox regulation of the transcriptional repressor Bach1 Numazawa, S, Ishikawa, M, Yoshida, T	Free Radic Biol Med	2005

Participants

Input

Output

Participates

as an event of

Regulation of BACH1 activity (Homo sapiens)

Catalyst Activity

protein tyrosine kinase activity of unknown kinase [nucleoplasm]

Physical Entity

unknown kinase [nucleoplasm] (Homo sapiens)

Activity

protein tyrosine kinase activity (GO:0004713)

Authored

Stephan, R (2020-11-23)

Reviewed

Somers, J (2021-01-23)

Created

Rothfels, K (2022-01-18)

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