Wee1-mediated phosphorylation of Cyclin A:phospho-Cdc2 complexes

Stable Identifier
R-HSA-170156
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
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Wee1-mediated phosphorylation of Cyclin A:phospho-Cdc2 complexes
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The human Wee1 kinase phosphorylates Cdc2 on tyrosine 15 inactivating the cyclin:CDK complex (Watanabe et al., 1995).

Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
protein tyrosine kinase activity of WEE1 [nucleoplasm]
Physical Entity
WEE1 [nucleoplasm]
Activity
protein tyrosine kinase activity (0004713)
Inferred From
Wee1-mediated phosphorylation of Cyclin B1:phospho-Cdc2 complexes (Homo sapiens)
Created
Matthews, L  (2005-12-23)