Reactome | Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3

Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3

Stable Identifier

R-HSA-450333

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3

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The MAPK level components of this cascade are p38MAPK-alpha, -beta, -gamma and -sigma. All of those isoforms are activated by phosphorylation of the Thr and Tyr in the Thr-Gly-Tyr motif in their activation loops.

Literature References

PubMed ID	Title	Journal	Year
8622669	MKK3- and MKK6-regulated gene expression is mediated by the p38 mitogen-activated protein kinase signal transduction pathway Davis, RJ, Whitmarsh, AJ, Derijard, B, Raingeaud, J, Barrett, T	Mol Cell Biol	1996
7535770	Pro-inflammatory cytokines and environmental stress cause p38 mitogen-activated protein kinase activation by dual phosphorylation on tyrosine and threonine Gupta, S, Davis, RJ, Ulevitch, RJ, Han, J, Raingeaud, J, Dickens, M, Rogers, JS	J Biol Chem	1995