Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3

Stable Identifier
R-HSA-450333
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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The MAPK level components of this cascade are p38MAPK-alpha, -beta, -gamma and -sigma. All of those isoforms are activated by phosphorylation of the Thr and Tyr in the Thr-Gly-Tyr motif in their activation loops.

Literature References
PubMed ID Title Journal Year
7535770 Pro-inflammatory cytokines and environmental stress cause p38 mitogen-activated protein kinase activation by dual phosphorylation on tyrosine and threonine

Raingeaud, J, Gupta, S, Rogers, JS, Dickens, M, Han, J, Ulevitch, RJ, Davis, RJ

J Biol Chem 1995
8622669 MKK3- and MKK6-regulated gene expression is mediated by the p38 mitogen-activated protein kinase signal transduction pathway

Raingeaud, J, Whitmarsh, AJ, Barrett, T, Derijard, B, Davis, RJ

Mol Cell Biol 1996
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
MAP kinase kinase activity of p-S189,T193-MAP2K3, p-S207,T211-MAP2K6 [nucleoplasm]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created