Reactome | SGK phosphorylates SRF

SGK phosphorylates SRF

Stable Identifier

R-HSA-9612509

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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Signal Transduction (Homo sapiens)

- Signaling by Receptor Tyrosine Kinases (Homo sapiens)
  - Signaling by NTRKs (Homo sapiens)
    - Signaling by NTRK1 (TRKA) (Homo sapiens)
      - Nuclear Events (kinase and transcription factor activation) (Homo sapiens)
        
        NGF-stimulated transcription (Homo sapiens)
        
        SGK phosphorylates SRF (Homo sapiens)

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Serum/glucticocorticoid kinase (SGK) phosphorylates SRF at serine residue 103 in response to multiple upstream stimuli (Tyan et al, 2008). Phosphorylation of SRF and CREB1 by SGK contributes to the SGK-dependent expression of EGR1, an immediate early gene with roles in neuronal development, (David et al, 2005; Tyan et al, 2008; reviewed in Pagel and Deindl, 2011).

Literature References

PubMed ID	Title	Journal	Year
22053691	Early growth response 1--a transcription factor in the crossfire of signal transduction cascades Deindl, E, Pagel, JI	Indian J. Biochem. Biophys.	2011
15733869	Serum/glucocorticoid-inducible kinase can phosphorylate the cyclic AMP response element binding protein, CREB David, S, Kalb, RG	FEBS Lett.	2005
18088355	Serum- and glucocorticoid-inducible kinase 1 enhances zif268 expression through the mediation of SRF and CREB1 associated with spatial memory formation Lin, CL, Lee, EH, Ma, YL, Tyan, SW, Tsai, MC	J. Neurochem.	2008