SGK phosphorylates SRF

Stable Identifier
R-HSA-9612509
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Serum/glucticocorticoid kinase (SGK) phosphorylates SRF at serine residue 103 in response to multiple upstream stimuli (Tyan et al, 2008). Phosphorylation of SRF and CREB1 by SGK contributes to the SGK-dependent expression of EGR1, an immediate early gene with roles in neuronal development, (David et al, 2005; Tyan et al, 2008; reviewed in Pagel and Deindl, 2011).

Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine kinase activity of p-T256,S422-SGK1 [nucleoplasm]
Physical Entity
Activity
Orthologous Events
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Reviewed
Created