SGK phosphorylates SRF

Stable Identifier
R-HSA-9612509
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Serum/glucticocorticoid kinase (SGK) phosphorylates SRF at serine residue 103 in response to multiple upstream stimuli (Tyan et al, 2008). Phosphorylation of SRF and CREB1 by SGK contributes to the SGK-dependent expression of EGR1, an immediate early gene with roles in neuronal development, (David et al, 2005; Tyan et al, 2008; reviewed in Pagel and Deindl, 2011).

Participants
Participates
Catalyst Activity

protein serine/threonine kinase activity of p-T256,S422-SGK1 [nucleoplasm]

Orthologous Events
Authored
Reviewed
Created
Cite Us!