Phosphorylation of Cdh1 by Cyclin A:Cdk2

Stable Identifier
R-HSA-174079
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
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Phosphorylation of Cdh1 by Cyclin A:Cdk2
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At the G1/S transition, the Cdh1 subunit of the APC:Cdh1 complex is phosphorylated by Cyclin A:Cdk2 and dissociates from APC/C. This inactivates APC/C and permits the accumulation of cell cycle proteins required for DNA synthesis and entry into mitosis.

Literature References
PubMed ID Title Journal Year
10548110 Accumulation of cyclin B1 requires E2F and cyclin-A-dependent rearrangement of the anaphase-promoting complex

Lukas, C, Sorensen, CS, Kramer, E, Santoni-Rugiu, E, Lindeneg, C, Peters, JM, Lukas, J

Nature 1999
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
cyclin-dependent protein serine/threonine kinase activity of Cyclin A:phospho-Cdk(Thr 160):Cdh1:phosho-APC/C complex [nucleoplasm]
Physical Entity
Cyclin A:phospho-Cdk(Thr 160):Cdh1:phosho-APC/C complex [nucleoplasm]
Activity
cyclin-dependent protein serine/threonine kinase activity (0004693)
Orthologous Events
Phosphorylation of Cdh1 by Cyclin A:Cdk2 (Bos taurus)
Phosphorylation of Cdh1 by Cyclin A:Cdk2 (Canis familiaris)
Phosphorylation of Cdh1 by Cyclin A:Cdk2 (Danio rerio)
Phosphorylation of Cdh1 by Cyclin A:Cdk2 (Dictyostelium discoideum)
Phosphorylation of Cdh1 by Cyclin A:Cdk2 (Drosophila melanogaster)
Phosphorylation of Cdh1 by Cyclin A:Cdk2 (Gallus gallus)
Phosphorylation of Cdh1 by Cyclin A:Cdk2 (Mus musculus)
Phosphorylation of Cdh1 by Cyclin A:Cdk2 (Rattus norvegicus)
Phosphorylation of Cdh1 by Cyclin A:Cdk2 (Sus scrofa)
Phosphorylation of Cdh1 by Cyclin A:Cdk2 (Xenopus tropicalis)
Authored
Lorca, T  (2006-01-26)
Castro, A  (2006-01-26)
Reviewed
Peters, JM  (2006-03-28)
Created
Matthews, L  (2006-02-17)
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