Phosphorylation of Cdh1 by Cyclin A:Cdk2

Stable Identifier
R-HSA-174079
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Phosphorylation of Cdh1 by Cyclin A:Cdk2
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

At the G1/S transition, the Cdh1 subunit of the APC:Cdh1 complex is phosphorylated by Cyclin A:Cdk2 and dissociates from APC/C. This inactivates APC/C and permits the accumulation of cell cycle proteins required for DNA synthesis and entry into mitosis.

Literature References
PubMed ID Title Journal Year
10548110 Accumulation of cyclin B1 requires E2F and cyclin-A-dependent rearrangement of the anaphase-promoting complex

Lukas, J, Lindeneg, C, Peters, JM, Sorensen, CS, Kramer, E, Lukas, C, Santoni-Rugiu, E

Nature 1999
Participants
Input
Output
Participates
as an event of
Catalyst Activity

cyclin-dependent protein serine/threonine kinase activity of Cyclin A:phospho-Cdk(Thr 160):Cdh1:phosho-APC/C complex [nucleoplasm]

Physical Entity
Cyclin A:phospho-Cdk(Thr 160):Cdh1:phosho-APC/C complex [nucleoplasm] (Homo sapiens)
Activity
cyclin-dependent protein serine/threonine kinase activity (GO:0004693)
Orthologous Events
Phosphorylation of Cdh1 by Cyclin A:Cdk2 (Bos taurus)
Phosphorylation of Cdh1 by Cyclin A:Cdk2 (Canis familiaris)
Phosphorylation of Cdh1 by Cyclin A:Cdk2 (Danio rerio)
Phosphorylation of Cdh1 by Cyclin A:Cdk2 (Dictyostelium discoideum)
Phosphorylation of Cdh1 by Cyclin A:Cdk2 (Drosophila melanogaster)
Phosphorylation of Cdh1 by Cyclin A:Cdk2 (Gallus gallus)
Phosphorylation of Cdh1 by Cyclin A:Cdk2 (Mus musculus)
Phosphorylation of Cdh1 by Cyclin A:Cdk2 (Rattus norvegicus)
Phosphorylation of Cdh1 by Cyclin A:Cdk2 (Schizosaccharomyces pombe)
Phosphorylation of Cdh1 by Cyclin A:Cdk2 (Sus scrofa)
Phosphorylation of Cdh1 by Cyclin A:Cdk2 (Xenopus tropicalis)
Authored
Castro, A  (2006-01-26)
Lorca, T  (2006-01-26)
Reviewed
Peters, JM  (2006-03-28)
Created
Matthews, L  (2006-02-17)
Cite Us!