I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK (IP5-2K) in the nucleus

Stable Identifier
R-HSA-1855176
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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In the nucleus, inositol-pentakisphosphate 2-kinase (IPPK - also known as IP5-2K) phosphorylates inositol 1,3,4,5,6-pentakisphosphate (I(1,3,4,5,6)P5) to inositol 1,2,3,4,5,6-hexakisphosphate (IP6) (Verbsky et al. 2002, Brehm et al. 2007, Choi et al. 2007).

Literature References
PubMed ID Title Journal Year
17702752 Purification, sequencing, and molecular identification of a mammalian PP-InsP5 kinase that is activated when cells are exposed to hyperosmotic stress

Choi, JH, Williams, J, Cho, J, Falck, JR, Shears, SB

J Biol Chem 2007
17705785 Intracellular localization of human Ins(1,3,4,5,6)P5 2-kinase

Brehm, MA, Schenk, TM, Zhou, X, Fanick, W, Lin, H, Windhorst, S, Nalaskowski, MM, Kobras, M, Shears, SB, Mayr, GW

Biochem J 2007
12084730 The synthesis of inositol hexakisphosphate. Characterization of human inositol 1,3,4,5,6-pentakisphosphate 2-kinase

Verbsky, JW, Wilson, MP, Kisseleva, MV, Majerus, PW, Wente, SR

J Biol Chem 2002
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
inositol pentakisphosphate 2-kinase activity of IPPK [nucleoplasm]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea
Authored
Reviewed
Created
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