Reactome | I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK (IP5-2K) in the nucleus

I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK (IP5-2K) in the nucleus

Stable Identifier

R-HSA-1855176

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK (IP5-2K) in the nucleus

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In the nucleus, inositol-pentakisphosphate 2-kinase (IPPK - also known as IP5-2K) phosphorylates inositol 1,3,4,5,6-pentakisphosphate (I(1,3,4,5,6)P5) to inositol 1,2,3,4,5,6-hexakisphosphate (IP6) (Verbsky et al. 2002, Brehm et al. 2007, Choi et al. 2007).

Literature References

PubMed ID	Title	Journal	Year
17705785	Intracellular localization of human Ins(1,3,4,5,6)P5 2-kinase Brehm, MA, Schenk, TM, Zhou, X, Fanick, W, Lin, H, Windhorst, S, Nalaskowski, MM, Kobras, M, Shears, SB, Mayr, GW	Biochem J	2007
17702752	Purification, sequencing, and molecular identification of a mammalian PP-InsP5 kinase that is activated when cells are exposed to hyperosmotic stress Choi, JH, Williams, J, Cho, J, Falck, JR, Shears, SB	J Biol Chem	2007
12084730	The synthesis of inositol hexakisphosphate. Characterization of human inositol 1,3,4,5,6-pentakisphosphate 2-kinase Verbsky, JW, Wilson, MP, Kisseleva, MV, Majerus, PW, Wente, SR	J Biol Chem	2002