Reactome | MAPKAPK2 phosphorylates CREB at Serine 133

MAPKAPK2 phosphorylates CREB at Serine 133

Stable Identifier

R-HSA-199917

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

Locations in the PathwayBrowser

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Immune System (Homo sapiens)

- Cytokine Signaling in Immune system (Homo sapiens)
  - Signaling by Interleukins (Homo sapiens)
    - Interleukin-17 signaling (Homo sapiens)
      - MAP kinase activation (Homo sapiens)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
        
        CREB phosphorylation (Homo sapiens)
        
        MAPKAPK2 phosphorylates CREB at Serine 133 (Homo sapiens)
- Innate Immune System (Homo sapiens)
  - Toll-like Receptor Cascades (Homo sapiens)
    - Toll Like Receptor 10 (TLR10) Cascade (Homo sapiens)
      - MyD88 cascade initiated on plasma membrane (Homo sapiens)
        
        MAP kinase activation (Homo sapiens)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
        
        CREB phosphorylation (Homo sapiens)
        
        MAPKAPK2 phosphorylates CREB at Serine 133 (Homo sapiens)
    - Toll Like Receptor 2 (TLR2) Cascade (Homo sapiens)
      - Toll Like Receptor TLR1:TLR2 Cascade (Homo sapiens)
        
        MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
        
        MAP kinase activation (Homo sapiens)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
        
        CREB phosphorylation (Homo sapiens)
        
        MAPKAPK2 phosphorylates CREB at Serine 133 (Homo sapiens)
      - Toll Like Receptor TLR6:TLR2 Cascade (Homo sapiens)
        
        MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
        
        MAP kinase activation (Homo sapiens)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
        
        CREB phosphorylation (Homo sapiens)
        
        MAPKAPK2 phosphorylates CREB at Serine 133 (Homo sapiens)
    - Toll Like Receptor 3 (TLR3) Cascade (Homo sapiens)
      - MAP kinase activation (Homo sapiens)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
        
        CREB phosphorylation (Homo sapiens)
        
        MAPKAPK2 phosphorylates CREB at Serine 133 (Homo sapiens)
    - Toll Like Receptor 4 (TLR4) Cascade (Homo sapiens)
      - MyD88-independent TLR4 cascade (Homo sapiens)
        
        TRIF(TICAM1)-mediated TLR4 signaling (Homo sapiens)
        
        MAP kinase activation (Homo sapiens)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
        
        CREB phosphorylation (Homo sapiens)
        
        MAPKAPK2 phosphorylates CREB at Serine 133 (Homo sapiens)
      - MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
        
        MAP kinase activation (Homo sapiens)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
        
        CREB phosphorylation (Homo sapiens)
        
        MAPKAPK2 phosphorylates CREB at Serine 133 (Homo sapiens)
    - Toll Like Receptor 5 (TLR5) Cascade (Homo sapiens)
      - MyD88 cascade initiated on plasma membrane (Homo sapiens)
        
        MAP kinase activation (Homo sapiens)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
        
        CREB phosphorylation (Homo sapiens)
        
        MAPKAPK2 phosphorylates CREB at Serine 133 (Homo sapiens)
    - Toll Like Receptor 7/8 (TLR7/8) Cascade (Homo sapiens)
      - MyD88 dependent cascade initiated on endosome (Homo sapiens)
        
        TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Homo sapiens)
        
        MAP kinase activation (Homo sapiens)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
        
        CREB phosphorylation (Homo sapiens)
        
        MAPKAPK2 phosphorylates CREB at Serine 133 (Homo sapiens)
    - Toll Like Receptor 9 (TLR9) Cascade (Homo sapiens)
      - MyD88 dependent cascade initiated on endosome (Homo sapiens)
        
        TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Homo sapiens)
        
        MAP kinase activation (Homo sapiens)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
        
        CREB phosphorylation (Homo sapiens)
        
        MAPKAPK2 phosphorylates CREB at Serine 133 (Homo sapiens)

Signal Transduction (Homo sapiens)

- Signaling by Receptor Tyrosine Kinases (Homo sapiens)
  - Signaling by NTRKs (Homo sapiens)
    - Signaling by NTRK1 (TRKA) (Homo sapiens)
      - Nuclear Events (kinase and transcription factor activation) (Homo sapiens)
        
        CREB phosphorylation (Homo sapiens)
        
        MAPKAPK2 phosphorylates CREB at Serine 133 (Homo sapiens)

General

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MAPKAPK2 phosphorylates CREB at Serine 133

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p38 MAPK activation leads to CREB Serine 133 phosphorylation through the activation of MAPKAP kinase 2 or the closely related MAPKAP kinase 3.

Literature References

PubMed ID	Title	Journal	Year
7551568	Serine 133-phosphorylated CREB induces transcription via a cooperative mechanism that may confer specificity to neurotrophin signals Bonni, A, Ginty, DD, Dudek, H, Greenberg, ME	Mol. Cell. Neurosci.	1995