Active p38 MAPK phosphorylates MAPKAPK5

Stable Identifier
R-HSA-3239019
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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MAPK14 (p38 alpha) and MAPK11 (p38 beta) phosphorylate MAPKAPK5 (PRAK) on threonine residue 182, located in the conserved LMTP site in the T-loop of the kinase domain. Phosphorylation of T182 is necessary for the MAPKAPK5 catalytic activity (New et al. 1998).

Literature References
PubMed ID Title Journal Year
9628874 PRAK, a novel protein kinase regulated by the p38 MAP kinase

New, L, Jiang, Y, Zhao, M, Liu, K, Zhu, W, Flood, LJ, Kato, Y, Parry, GC, Han, J

EMBO J. 1998
Participants
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Catalyst Activity
Catalyst Activity
Title
protein serine/threonine kinase activity of phospho-p38 MAPK: MAPKAPK5 [nucleoplasm]
Physical Entity
Activity
Orthologous Events
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